B cells and production of antibodies 1

Question 1

what does gene rearrangement of B and T cells lead to

Answer 1

• increases chance of producing a functional antigen receptor
• allows production of B cells that recognise a single antigen with high specificity

Question 2

where do B cells originate from

Answer 2

common lymphoid progenitor cell

Question 3

when leaving bone marrow what happens to B lymphocytes

Answer 3

• maturation dependent on antigen-presentation in lymph nodes

Question 4

what are the earliest committed B cells

Answer 4

• Pro- B cel
• development relates to gene rearrangement events

Question 5

where to B cells initially develop

Answer 5

bone marrow

Question 6

what does gene rearrangement determine

Answer 6

antigen binding capacity of B cell receptor

Question 7

where does B cell differentiation occur

Answer 7

• upon antigen presentation
• in peripheral lymphoid tissue and organs, germinal centres and lymph nodes

Question 8

upon class switching what does activated B cells produce

Answer 8

• memory cells
• plasma cells

Question 9

when a cell matures what does it loose and grain

Answer 9

loss of generic functions
gain of specific functions

Question 10

what is B cell development dependent on

Answer 10

stromal cells in bone marrow

Question 11

what is the function of stromal cells

Answer 11

• contact with developing lymphocytes
• signalling by membrane bound or soluble cytokines

Question 12

what is antigen binding diversity generated by

Answer 12

• recombination
• random H/L chain combinations
• somatic hypermutation