Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > B cell Immunity- L10 > Flashcards

B cell Immunity- L10 Flashcards

1
Q

B cells develop in the

A

Bone marrow, called mature naive B cells when they leave the marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

B cells develop from what cell with what marker?

A

Pluripotent hematopoietic stem cells with marker CD34

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Common lymphoid progenitors have what marker?

A

CD34 and CD10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

B-cell precursors have what markers?

A

CD34, CD10, CD127

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pro-B cells have what markers?

A

CD34, CD10, CD127, CD19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What happens in the early pro B stage?

A

D-J rearrangement of heavy chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What happens in the late pro B stage?

A

V-DJ rearrangement of heavy chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What happens in large pre-B cells stage?

A

VDJ is rearranged and mu heavy chain of Ig is made

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What happens in small pre-B cell stage?

A

VDJ is rearranged, V-J of light chain is rearranging, and mu chain is in the ER of Ig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What happens in an immature B cell?

A

VCJ is rearranged, VJ is rearranged, gamma or kappa of light chain IgG is made, IgM is on surface.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What percentage of cells produce a productive heavy chain and survive to become pre-B cells?

A

About 50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What region does the light chain not have?

A

D region

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the two checkpoints in becoming an immature B cell?

A
  1. Pre-B cell receptor
  2. B cell receptor

If these aren’t met the cell will apoptose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Burkitt’s lymphoma

A
  • Chromosomal aberration during B cell development

- MYC and Ig on chromosomes 8 and 14 respectively get translocated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

B-1 cell characterstics

A
  • Produced in fetus
  • Few N regions in VDJ junctions
  • Smaller V region repertoire
  • Primarily located in peritoneal and pleural cavities
  • Self-renewing
  • More IgM than IgG
  • Little somatic mutation
  • Little memory development
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Central tolerance

A
  • Avoiding self
  • If no reaction with a self antigen–moves to blood to express IgD and IgM
  • If reaction with self the immature B cell is retained in bone marrow and RAG gene is reexpressed to try and rearrange again. Will continue rearranging until a nonself receptor is expressed.
17
Q

Anergy

A

Interaction of immature B cells with monomeric antigen induces a state inactivity called anergy. Signaled to make IgD and become unresponsive to antigen.

18
Q

B cell trafficking in the periphery

A
  • B cell area in the cortex

- Enter through HEV

19
Q

Chemokine CCL21

A

Attracts immature B cells to HEV and into lymph node

20
Q

CCL19

A

Attracts B cells into lymph node

21
Q

Chemokine CXCL13

A

Attracts B cells into the primary follicle

22
Q

Follicular dendritic cells

A

Drive the final maturation of B cells

23
Q

B cells mature where?

A

Germinal centers of lymph nodes

24
Q

How do B cells signal?

A
  • Cross linking of B-cell receptors by antigen
  • Clustering of antigen receptors allows receptor-associated kinases to phosphorylate ITAMs
  • SyK binds to doubly phosphorylated ITAMs and is activated on binding
25
Q

B cell coreceptor 1

A
  • Consists of CD81, CD19, and CR2
  • Binding of CR1 to C3b bound to a pathogen facilitates its cleavage by factor 1 to iC3b and C3d.
  • CR2 component of the B-cell co-receptor can then bind to C3d
26
Q

B cell coreceptor 2

A

-Cooperate in B-cell activation by a pathogen or a soluble agent

27
Q

T-cell independent antigens

A
  • B1 cells generally T independent

- Antigen binds B cell coreceptor which activates it

28
Q

How do B and T cells find each other?

A
  • B cells look for specific antigen displayed by FDC is B cell area
  • T cells look for specific antigen presented by dendritic cells in T cell area
  • When T cells proliferate, B cells move toward them
29
Q

Somatic hypermutation occurs where?

A

Germinal center. It’s a site of intense competition for limiting antigen

Immunology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions