Axon Guidance Molecules: Comm & Slit Flashcards
1
Q
What is Comm and what does it do?
A
A transmembrane protein in commissural axons.
Kelemen et al (2002) found It promotes midline crossing by sorting Robo from the Golgi to the endosomal pathway for degradation. Thus preventing Robos membrane insertion
2
Q
What regulates slit-Robo repulsion in vertebrates?
A
We don’t know
A comm homolog hasn’t been identified in vertebrates, only Drosophila
3
Q
Explain the other mechanism that regulates chemorepulsive signalling in precrossing axons
A
Evans et al (2015) found that Robo2 is expressed in midline cells at the same time axons cross.
It binds to robo1 on commissural axons this inhibiting slit mediated repulsion
4
Q
Who discovered that Comm associates with Robo to recruit it for lysosomal degradation ?
A
Kelemen et al (2002)
