ADHD

Question 1

What are the 3 major ADHD subtypes?

Answer 1

• Predominantly hyperactive- impulsive
• Predominantly inattentive
• Combination

Question 2

What genes are linked to ADHD?

Answer 2

GRM7

Encodes a glutamate R subunit

Question 3

Name the ADHD treatments

Answer 3

• Methylphenidate (Ritalin)
[Prevents reuptake of Dopamine & causes reverse transport]

• Atomoxetine
[Prevents reuptake of NA]

Question 4

What are the 3 types of validity animal models require?

Answer 4

• Face Validity
(The ability to mimic behavioural characteristics of ADHD)

• Construct Validity
(Conform to a theoretical rationale of ADHD)

• Predictive Validity
(Ability to predict previously unknown aspects of behaviour, genetics & neurobiology of ADHD)

Question 5

What is the strategy to studying ADHD?

Answer 5

1) reverse genetics [identify gene in human patients]
2) clone the gene
3) knock it down/ over express it in animal model
4) Measure the behaviour
5) See whether the gene has a similar function in the animal model as it does in human patients

Question 6

Name the mouse/rat model in ADHD

Answer 6

• spontaneous hypertensive rat
• Dopamine transporter KO mouse
• Coloboma mutant mouse
• 6-OHDA lesions rat