Axis and glycemia Flashcards

1
Q

Quels sont les medicaments insulinosecreteurs?

A

Sulfamide, glinides, agoniste GLP1, inhibiteurs DPP4

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2
Q

Que font les biguanides?

A

augmentation AMPK > diminution glucose hepatique > inhib capture + utilisation glucose

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3
Q

Que font les sulfamides

A

stimule insuline par fixation SUR > fermeture canaux potassique ATP-dep = depolarisation cellule b > secretion

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4
Q

Repaglinide?

A

SUR mais pas le meme site que sulfamide

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5
Q

inhibiteurs alpha-glucosidase?

A

inhibition hydrolyse glucides - monosacch > dim hyperglycemie post prand

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6
Q

Agoniste GLP1?

A

Synthetique proche GLP1 = activation Rc

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7
Q

inhibiteur DPP4?

A

inhibition enzyme qui inactive GLP1 > secretion insu

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8
Q

inhibiteur SGLT2?

A

inhibition reabs tubulaire glucose via cotransporteur SGLT2

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9
Q

Traitement deficit somatotrope?

A

GH synthetique recombinante
IGF-1 recombinant

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10
Q

Traitement hypersecretion somatotrope

A

Somatostatinomimetiques
Antagoniste Rc GH

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11
Q

Traitement insufficance surrenalienne

A

Glucocorticoides de synthese d’urgence et prolongés mais suppression axe HH surrenalien car retrocontrole negatif

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12
Q

traitement maladie de Cushing

A

Hypercorticisme traité par chirurgie hypophysaire ou radiotherapie

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13
Q

Traitement hypothyroidie

A

Levothyroxine et Liothyronine analogues substitufis ou inhibition TSH si cancer

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14
Q

Traitement hyperthyroidie

A

Pas d’antagoniste de TR mais antithyroidien de synthese surtout pour Basedow

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15
Q

Quand donner un traitement agoniste GnRH

A

testo, oestro, progestatif (contraception), gonadotrophines humaines (induction ovulation ou hypofertilité) et analogue GnRH (castration chimique)

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16
Q

Quand donner traitement antagoniste gonadotrope

A

Antagoniste recepteur androgene (anti-virilisation, cancer prostate)
modulateur selectifs des recepteurs oestrogenes (anta ou ago dependant tissu)
antagoniste rc progesterone (abortif)
antagoniste rc GnRH (cancer prostate)
inhibition production androgene (enzymes)
inhibiteur aromatase (anti-oestro)

17
Q

Traitement hypersecretion prolactine

A

agoniste recepteur dopa D2