Awesome Review Flashcards
First Step to determine obstructive or restrictive disease?
Total Lung Capacity
After maximal inhalation
PFT ratio to determine obstructive?
FEV1/FVC
Positive Broncodilator challenge to diagnose asthma?
Increase of FEV1 of 12% or increase of 200 mL
What causes fixed extra thoracic obstruction?
Draw it
Diagnosis
Tumor and Tracheal stenosis
Dx- Bronchoscopy
What causes dynamic extrathoracic obstruction?
Draw it
Diagnosis
Epiglottis and vocal cord dysfunction
Blunted inhalation, air coming in sucks
Dx- indirect laryngoscopy
What is DLCO in PE?
What is DLCO in CO poisoning?
Low
Normal
If you want to wean down ICS when treating asthma, what to give?
Leukotriene Modifiers
When to give Omalizumab?
Serum IgE 30-700
Evidence of allergies of perennial aeroallergen
Eosinophilia
What are new IL 5 antagonist monoclonal antibodies to treat eosinophilic asthma?
Reslizumab and Mepolizumab
Dx Allergic Bronchopulmonary Aspergillosis
+ skin test to Aspergillus
Increased IgE and peripheral eosinophilia
Brown mucus plugs
CXR- transient infiltrate, pleural thickening, atelectasis, proximal bronchiectasis
CXR difference btwn Chronic Eosinophilic PNA and Acute Eosinophilic PNA?
Chronic- peripheral infiltrate
Acute- center infiltrate/ground glass
Tx Alveolar Proteinosis
Whole Lung Lavage bc Shitty macrophages cause build up of surfactant in lung
If severe COPD on SABA, LABA, LA-anticholinergic, and pulm rehab, what’s next?
Roflumifast/Daliresp
Phosphodiesterase 4 inhibitor
Contraindicated in Liver Impairment
When do you need home oxygen in COPD?
PaO2 88%
Or Hct >55%
What can you do for upper lobe emphysema when FEV1 less than 50% but greater than 20%?
If less than 20%?
Lung Volume Reduction decreases mortality
Lung transplant if FEV1
Dx Dyskinetic Cilia Syndrome (aka Kartagener’s syndrome)
Screen- sperm motility
Confirm- testicular biopsy or biopsy of bronchi or sinus
Features of Dyskinetic Cilia Syndrome
Bronchiectasis
Sinusitis
Infertility!
Situs inversus
Leading bacteria that increases mortality in cystic fibrosis
Cepacia Burkholderia
Treat with Bactrim
Treat severe Bronchiectasis with bleed
Bronchial artery embolization
What is IgE and eosinophilia in hypersensitivity pneumonitis?
NORMAL