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CP exam 2 > Autonomics Pharm > Flashcards

Autonomics Pharm Flashcards

1
Q

Sweat gland innervation

A

Sympathetic

ACh - mAChR

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2
Q

Cardiac, smooth muscle, gland cells, nerve terminal parasympathetic innervation

A

ACh - mAChR

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3
Q

Cardiac and smooth muscle, gland cells, nerve terminals sympathetic

A

Norepinephrine - alpha and beta receptors

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4
Q

Renal vascular smooth muscle innervation

A

Sympathetic

Dopamine

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5
Q

Skeletal muscle

A

Somatic innervation

ACh — nAChR

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6
Q

A1 receptors…

A

Stimulate contraction of all SM; primary mode of controlling vascular smooth muscle vasoconstriction

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7
Q

B2 receptors..

A

Relax smooth muscle

Cause vasodilation and are important in lungs, GI, etc

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8
Q

Muscarinic receptors

A

Contract smooth muscle

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9
Q

M2 receptor

A

Located in heart, nerves, and SM
GPCR Gi
Inhibits AC, decreases cAMP, and activates K+

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10
Q

M3 receptor

A

Located in glands, SM, and endothelium
GPCR Gq
Activates PLC, IP3, and DAG cascade

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11
Q

M1

A

Located in CNS and gangli
GPCR Gq
Activates PLC, IP3, and DAG cascade

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12
Q

M4

A

Located in CNS
GPCR Gi
Inhibits Ac, decreases cAMP, activates K+

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13
Q

M5

A

Located in CNS, GPCR Gq, activates PLC, IP3, and DAG cascade

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14
Q

Nm

A

SKM NMJ
Ligand gated
Na+, K+ depolarize get ion channel

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15
Q

Nn

A

Post ganglionic cell body, dendrites, CNS
Ligand gated
Na+/K+ depolarizing ion channel

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16
Q

Alpha 1

A

Gq: increases PLC, IP3, and DAG as well as intracellular Ca2+
Responds to Epi and NE
Causes contraction

17
Q

Alpha 2

A

Gi: decreases AC and cAMP
Responds to Epi and NE
Located in pancreatic islets, platelets, nerve terminals, and vascular smooth muscle

Causes decreased insulin secretion

18
Q

Beta1

A

Gs
Increases AC, cAMP, L-type Ca2+ channel opening

Responds equally to Epi and NE
Found in heart and juxtaglomerular cells

Increases renin secretion, increases force and rate of contraction via the AV node

19
Q

Beta2

A

Gs
Increases AC
Responses more strongly to Epi and NE

Found in SM and SKM

Causes relaxation

20
Q

Beta3

A

Gs: increases AC
Responds to NE more than Epi

Found in adipose tissue and will cause lipolysis

CP exam 2 (6 decks)

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