Autonomics: Cholinomemetics

Question 1

What cholinergic receptors does carbacol stimulate?

Answer 1

Both nicotinic and muscarinic – think of the guy inhaling the cigarette smoke from below while looking at the motorcycles

Question 2

Where do M2 muscarinic channels affect the heart?

Answer 2

The atria – specifically through the SA and AV nodes (think of the girl with the lower part of her jacket torn off)

Question 3

In what circumstances do you administer bethanecol?

Answer 3

For non-obstructive bowel and bladder disorders (such as post-op ileus, megacolon, or neurogenic bladder); think of beth the construction worker pouring cement next to the “do not obstruct” sign

Question 4

Cholinomimetics mimic ____________; they are also called parasympathomimetics.

Answer 4

acetylcholine (“enjoy an acetyl-Cola”)

Question 5

What is the main use of pilocarpine?

Answer 5

Stimulate salivary glands (useful for those with Sjögren’s or radiation damage) and reduce IOP for glaucoma

Question 6

Why does M3 activation lead to vasodilation?

Answer 6

Because the receptor also activates NO; without this (such as in the case of endothelial cell damage) muscarinic agonists do lead to vasoconstriciton

Question 7

The Gq receptors couple to the ________ pathway.

Answer 7

IP3-DAG (think of the three dogs riding with the man on the motorcycle)

Question 8

Muscarinic agonists _________ intraocular pressure.

Answer 8

reduce

Question 9

In addition to aggravating asthma and COPD, what disorder can cholinomimetics aggravate?

Answer 9

Peptic ulcer disease (think of methacholine)

Question 10

Where do M3 channels exist?

Answer 10

The smooth muscles and glands (think of the rear-most motorcycle rider with the smooth-muscle paint job and glandular sponge)