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AFN Pharm I > Autonomic System > Flashcards

Autonomic System Flashcards

1
Q

What NT is @ all ganglionic junctions in the PNS?

A

Ach

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2
Q

The _________ receptor via the NT _________ is the only cholinergic receptor found in a sympathetic neuronal pathway that acts on what end target organ?

A

Muscarinic receptor

Ach

Sweat glands

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3
Q

What % does the adrenal medulla release NE and Epi comparitively into the blood stream?

A

Epi = 80-90%

NE = 10-20%

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4
Q

Is Ach a tertiary or quaternary ammonium ester

A

Quaternary

Doesnt cross BBB

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5
Q

Which crosses the BBB, tertiary or quaternary

A

Tertiary

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6
Q

Name the 5 key elements of NT fxn

A

Synthesis

Storage

Release

Termination of action

Receptor effects

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7
Q

Ach is hydrolzed in ___ ms by acetylcholinesterase

A

15ms

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8
Q

AchE metabolizes ________ molecules of Ach in 1 sec

A

25,000

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9
Q

2 other names for AchE

A

True cholinesterase

Specific cholinesterase

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10
Q

Is Ach recycled or reused?

A

No

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11
Q

Adrenergic fibers are stimulated by _____

A

Ach

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12
Q

What 2 NTs are in adrenergic near-effector junctions

A

NE

Dopamine

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13
Q

Anatomically analogous to post-ganglionic sympathetic fibers

A

Adrenal medullary cells

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14
Q

What 2 adrenergic receptors are found on the presynaptic membrane

A

A2

B1??

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15
Q

Which adrenergic receptor fxns via positive feedback

A

B1

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16
Q

Denervation supersensitivity is an extreme form of _____-regulation

A

Up-regulation

17
Q

What 4 adrenergic receptors stimulation adenylyl cyclase?

A

B1 B2 B3

D1

18
Q

What 2 adrenergic receptors inhibit adenylyl cyclase?

A

A2

D2

19
Q

Prototype for sympathomimetics

A

Phenylethylamine

20
Q

Prototype for beta antagonists

A

Propranolol

21
Q

What receptor is found on PNS & SNS autonomic ganglia

A

Nn receptors

22
Q

This NT is probably a postganglionic sympathetic transmitter in renal blood vessels

A

Dopamine

23
Q

This NT may have presynaptic effects on excitatory ENS nerve terminals & has some relaxant effects on the gut.

A

GABA

24
Q

This NT is an important transmitter or cotransmitter at excitatory neuron-to-neuron junctions in the ENS

A

Serotonin

25
Q

Which M receptors increase IP3/DAG/Ca++

A

M1 M3 M5

26
Q

Which M receptors inhibit adenylyl cyclase & open K+ channels

A

M2 M4

27
Q

Which N receptor is somatic

A

Nm

28
Q

This type of receptor opens Na+ & K+ channels causing depolarization

A

N receptors

29
Q

Which M receptors synthesize and release EDRF

A

M3 M5

AFN Pharm I (7 decks)

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