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All the Drugs > Autonomic Rx > Flashcards

Autonomic Rx Flashcards

1
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Bethanchol</p>

A

<p>1) Activates Bowel and Bladder smooth m. Post-op and neurogenic ileus and urinary retention.

2) Direct Cholinomimetic.
4) Resistant to AchE.</p>

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2
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Carbachol</p>

A

<p>1) Glaucoma, pupillary contraction, and relief of intraocular pressure.

2) Direct Cholinomimetic.
4) Carbon copy of Ach</p>

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3
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Pilocarpine</p>

A

<p class=”large” style=”text-align:center”;>1) Potent stim of sweat, tears, saliva. Contracts ciliary m of eye (open angle) and pupillary sphincter (narrow angle)

2) Direct Cholinomimetic
4) Resistant to AchE</p>

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4
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Methacholine </p>

A

<p>1) Challenge test --> dx of asthma.
2) Direct Cholinomimetic, stim muscarinic r in airway</p>

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5
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Neostigmine</p>

A

<p>1) Post-op and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular jxn blockade (post-op).

2) Indirect Cholinomimetic; increases Ach.
4) No CNS penetration</p>

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6
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Pyridostigmine</p>

A

<p>1) Myasthenia gravis (long acting)

2) Indirect Cholinomimetic; increases Ach, increases strength.
4) No CNS penetration</p>

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7
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Edrophonium </p>

A

<p>1) Diagnosis of myasthenia gravis (short acting).
2) Indirect Cholinomimetic; increases endogenous Ach</p>

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8
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Physostigmine</p>

A

<p>1) Anticholinergic toxicity

2) Indirect Cholinomimetic; increases Ach.
4) crosses BBB</p>

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9
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Donepezil</p>

A

<p>1) Alzheimers

| 2) Indirect Cholinomimetic; increases Ach</p>

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10
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>ADE of all Cholinomimetics</p>

A

<p>Exacerbation of COPD, asthma, and peptic ulcers</p>

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11
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Organophosphate poisoning (e.g. Parathion)</p>

A

<p class=”large” style=”text-align:center”;>Irreversibly inhib AchE. (DUMBBELSS) Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal m and CNS, Lacrimation, Sweating, and Salivation</p>

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12
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Rx for Organophosphate poisoning</p>

A

<p>Atropine + Pralidoxime = regenerate active AchE</p>

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13
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Atropine Use/MOA</p>

A

<p>1) Blocks Organophosphate poisoning. Used to treat bradycardia and opthalmic applications
2) Muscarinic antagonist. </p>

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14
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Atropine ADE</p>

A

<p>3) Increase body temp, rapid pulse, dry mouth, dry/flushed skin, cycloplegia, constipation. Can cause acute angle-glaucoma in elderly, urinary retention in men with BPH, hyperthermia in infants</p>

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15
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Homatropine</p>

A

<p>1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist</p>

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16
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Tropicamide</p>

A

<p>1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist</p>

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17
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Benztropine</p>

A

<p>1) Rx for Parkinsons.
2) Muscarinic Antagonist</p>

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18
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Scopolamine</p>

A

<p>1) Motion sickness.
2) Muscarinic antagonist</p>

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19
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Tiotropium</p>

A

<p class=”large” style=”text-align:center”;>1) Rx for COPD, Asthma.
2) Muscarinic antagonist</p>

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20
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Ipratropium</p>

A

<p>1) Rx for COPD, Asthma.
2) Muscarinic antagonist</p>

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21
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Oxybutynin</p>

A

<p>1) Reduce urgency in mild cystitis and reduce bladder spasms.
2) Muscarinic Antagonist</p>

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22
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Glycopyrrolate</p>

A

<p>1) Parenteral: preop --> reduce airway secretions. PO: Rx for drooling, peptic ulcer
2) Muscarinic Antagonist</p>

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23
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Epinephrine</p>

A

<p>1) Anaphylaxis, glaucoma (open angle), asthma, hypotension
2) Sympathomimetics; A1, A2, B1, B2. LOW dose selective for B1</p>

24
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>NE</p>

A

<p>1) Hypotension (but low renal perfusion)
2) Sympathomimetics; A1, A2 > B1</p>

25
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Isoproterenol</p>

A

<p class=”large” style=”text-align:center”;>1) Torsade de pointes (tachycardia decr low QT interval), bradyarrhythmias (but can worsen ischemia)
2) Sympathomimetics; B1=B2</p>

26
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Dopamine</p>

A

<p>1) Shock (renal perfusion), heart failure
2) Sympathomimetic; D1 (low dose) >B (medium dose) >A (high dose), inotropic and chronotropic</p>

27
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Dobutamine</p>

A

<p>1) Heart failure, cardiac stress testing
2) Sympathomimetic; B1>B2, inotropic and chronotropic)</p>

28
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Phenylephrine</p>

A

<p>1) Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant)
2) Sympathomimetic; A1>A2</p>

29
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Albuterol</p>

A

<p>1) Acute asthma

| 2) Sympathomimetic; Selective B2-agonist (B2>B1)</p>

30
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Salmeterol</p>

A

<p>1) Long-term treatment of asthma or COPD control
2) Sympathomimetic; Selective B2-agonist (B2>B1)</p>

31
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Terbutaline</p>

A

<p>1) Reduce premature uterine contractions
2) Sympathomimetic; Selective B2-agonist (B2>B1)</p>

32
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Ritodrine</p>

A

<p>1) Reduces premature uterine contractions
2) Sympathomimetic; B2</p>

33
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Amphetamine</p>

A

<p>1) Narcolepsy, obesity, ADD
2) Indirect Sympathomimetic/general agonist, releases stored catecholamines</p>

34
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Ephedrine</p>

A

<p>1) Nasal decongestion, urinary incontinence, hypotension
2) Indirect sympathomimetic/general agonist, releases stored catecholamines</p>

35
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Cocaine</p>

A

<p>1) Causes vasoconstriction and local anesthesia

2) Indirect sympathomimetic/general agonist. Uptake inhibitor.
4) People use this to get high. Don't give B-blockers if cocaine intoxication suspected.</p>

36
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Clonidine</p>

A

<p>1) HTN esp w renal disease (no decr in blood flow to kidney)
2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow</p>

37
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Alpha-methyldopa</p>

A

<p>1) HTN esp w renal disease (no decr in blood flow to kidney)
2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow</p>

38
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Phenoxybenzamine</p>

A

<p class=”large” style=”text-align:center”;>1) Pheochromocytoma (b4 removing tumor)

2) Irreversible, Nonselective alpha blocker
3) Orthostatic hypotension, reflex tachycardia</p>

39
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Phentolamine</p>

A

<p>1) Give to pts on MAO-i who eat tyramine-containing foods
2) Reversible, Nonselective alpha blocker</p>

40
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Prazosin</p>

A

<p>1) HTN, urinary retention in BPH

2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA</p>

41
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Terazosin</p>

A

<p>1) HTN, urinary retention in BPH

2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA</p>

42
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Doxazoin</p>

A

<p>1) HTN, urinary retention in BPH

2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA</p>

43
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Tamsuolosin</p>

A

<p>1) HTN, urinary retention in BPH

2) A1 blocker
3) 1st dose orthostatic hypotension, dizziness, HA</p>

44
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Mirtazapine</p>

A

<p>1) Depression

2) A2 blocker
3) Sedation, incr serum cholesterol, incr appetite</p>

45
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Acebutolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Beta1-antagonist (partial Beta-agonist)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

46
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p class=”large” style=”text-align:center”;>Betaxolol</p>

A

<p class=”large” style=”text-align:center”;>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

47
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Esmolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Beta1-antagonist (short acting)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

48
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Atenolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

49
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Metoprolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Beta1-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

50
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Propanolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Non-selective B-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure sleep alteration). Use with caution in diabetics</p>

51
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Timolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Non-selective B-antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

52
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Pindolol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Non-selective B-antagonist (partial B-agonist)
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

53
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Labetalol</p>

A

<p>1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma

2) Non-selective A and B antagonist
3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics</p>

54
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Carvedilol</p>

A

<p>Non-selective A and B antagonist</p>

55
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

<p>Nadolol</p>

A

<p>Non-selective B antagonist</p>

All the Drugs (17 decks)

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