Autonomic Pharmacology

Question 1

Muscarinic AChR antagonist

Answer 1

ANTAgonist will relax smooth muscle

increase PARAsympathetics
-but nonselective

Question 2

Stomach and Intestine Sympathetic Activity

• Motility and tone
• sphincters
• secretion

Answer 2

• Motility and tone: decreases (a1,a2,b1,b2)
• sphincters: contraction (via a1)
• secretion : inhibition (via a2)

Question 3

Stomach and Intestine PARAsympathetic Activity

• Motility and tone
• sphincters
• secretion

Answer 3

• Motility and tone: increases (M2, M3)
• sphincters: relaxation (M2, M3)
• secretion: stimulation (M2, M3)

Question 4

Urinary Bladder
Sympathetic activity
-Detrusor
-Trigone and sphincter

Answer 4

• Detrusor: relaxation (via B2)

- Trigone and sphincter: contration (via a1)

Question 5

Urinary Bladder
Parasympathetic activity
-Detrusor
-Trigone and sphincter

Answer 5

• Detrusor: contraction (M3>M2)

- Trigone and sphincter: relaxation (M3>M2)

Question 6

Alpha 1 deals with ?

Answer 6

contraction of Smooth muscle

• VASCULAR smooth muscle
• pupil dilation
• uterine contaction

Question 7

B1 receptors

Answer 7

deals with HEART

increase HR
increase renin secretion

Question 8

A2

Answer 8

found presynaptic

suppress activation of sympathetics

decrease insulin

Question 9

side effect of MaChr agonist

Answer 9

asthma

bc increase SM contraction=> lung contraction=> asthma

Question 10

ACHE toxicty

- mneumonics

Answer 10

SLUDGE: Salivation, lacrimation, urination, defecation, gastrointestinal pain & gas, emesis

DUMBELS: defecation, urination, miosis, brochospasm, emesis, lacrimation, salivation

ingestion: GI symtoms occur first

localized sweating and muscle fasciculation