Autonomic Pharm Flashcards
Where are Nn receptors located?
on cell bodies in ganglia of both PANS and SANS and in the adrenal medulla
Where are Nm recepotrs located
On the skeletal muscle motor end plate innervated by somatic motor nerves
Where are M1-3 receptors located?
on all organs and tissues innervated by post-ganglionic nerves of the PANS and on thermoregulatory sweat glands innervated by the SANS
Aldosterone is released from the
adrenal cortex
Renin is released from the
juxtaglomerular cells in response to hypotension or increased sympathetic drive
Aldosterone MOA
DCT/CD: increase Na/ H20 retention; DECREASE K
Angiotensin II MOA
Vasoconstricts Efferent arteriole and systemic - increase TPR
Paralysis of accommodation - leading to only far vision
Cyclopegia
Muscarinic stimulation on the eye
Miosis (small) and accommodation
Alpha 1 (adrenergic) stimulation on the eye - radial muscles
Mydriasis (dilated), NO cycloplegia
MOA of Botulinum toxin (endotoxin from clostridium)
Binds synaptobrevin preventing Ach release
MOA of indirect-acting cholinomimetics
Target AchE for inhibition
3 Reversible AChE inhibitors
Edrophonium; Physostigmine; neostigimine
3 Irreversible AchE inhibitors
Echothiophate, malathion, parathion
Muscarinic Receptor activation does what to the eye
Sphincter: M3 (Gq) = contraction = miosis
Ciliary muscle: M3(Gq) = contraction = accommodation for near vision
Muscarinic Receptor Activation does what to the heart
SA node: M2 (Gi) - Decrease HR
AV node: M2 - decrease conduction velocity
DOES NOT AFFECT THE VENTRICLES
Muscarinic Receptor Activation does what to the Lungs?
Bronchioles: M3 - contraction = bronchospasm
Glands: M3 = secretion
Muscarinic Receptor Activation does what to the GI tract?
Stomach: M3 - Increase motility (Cramps)
Glands: M1 - Secretion (inc acid)
Intestine: M3 - Contraction = diarrhea, involuntary defecation
Muscarinic Receptor activation does what to the Bladder?
M3: Contraction (Detrusor), relaxation (trigone/sphincter), voiding, urinary incontinence
Muscarinic Receptor activation does what to sphincters?
M3: relaxation (except LES, which contracts)
Muscarinic Receptor activation does what to glands?
All M3 except GI tract, which are M1: Sweat (thermoregulatory), salivation, and lacrimation
What does Muscarinic Receptor activation do to the blood vessels (endothelium)
M3: Argine –> NO = dilation. No innvervation here so no effect of indirect agonist (only SANs effect, not PANS)
4 Muscarinic Agonists (direct-acting cholinomimetics)
Ach; Bethanechol; Methacholine; Pilocarpine
Muse of Bethanechol
Post op/neurogenic ileus; urinary retention
Muscarinic agonist
Use of Pilocarpine - a muscarinic agonist
Glaucoma, xerostomia, Increases sweating for a + sweat test in cystic fibrosis
7 Acetylcholinesterase Inhibitors (indirect-acting cholinomimetics)
Edrophonium; Physostigminie; Neostigmine; Pyridostigmine; Donepezil; tacrine; Organophosphates
Use of Edrophonium - an AChE inhibitor
Tensilon test for MG
Use of Physostigmine - an AChE inhibitor
Atrophine overdose, glaucoma
Uses of neostigmine, Pyridostigmine - AchE inhibitors
Ileus, urinary retention, myasthenia (Neo), reversal of Nm blockade (curare)
Use of Donepezil and Tacrine - AChe inhibitors
Alzheimer disease
Use of Organophosphates, AChE inhibitors
Glaucoma. Used as insecticides - malathiom, parathion and nerve gas (sarin). Irreversible, non-competitive (decrease Vmax
S/S of AChe inhibitor Poisoning
DUMB BELSS:
Diarrhea; urination; miosis; Bradycardia; Bronchoconstriction; Excitation; Lacrimation; Salivation; Sweating
Chronic toxicity of organophosphates
peripheral neuropathy with demylination - mimics MS
6 Muscarinic Receptor antagonists (anti-muscarinic)
Atropine; Tropicamide; Ipratropium; Scopalamine; Benztropine; Trihexyphenidyl