Autonomic Ns

Question 1

What are the 2 type of receptors?

Answer 1

Muscarinic and nicotinic

Question 2

What is a muscarinic receptor and give a few examples?

Answer 2

G protein coupled so ip3/dag system
M1 to M5
M3 - bladder

Question 3

What is a nicotinic receptor and give examples

Answer 3

Made up of 5 subunits, alpha 1 and 2, gamma and beta
Muscle receptor- n1
Ganglionic receptor - n2
Non selective cation channel

Question 4

What does the alpha 1 receptor activate?

Answer 4

Gq, stimulates ip3/dag … increases ca

Question 5

What does alpha 2 stimulate?

Answer 5

Activates gi, inhibits camp

Found presynaptically, decreases noradrenaline

Question 6

What system does renin affect?

Answer 6

Parasym- no effect

Symp- increases secretion from kidney

Question 7

What muscle controls contraction of pupil?

Answer 7

Sphincter papillae muscle which is mediated by the oculomotor nerve

Question 8

What is given as eye drops for people who have glaucoma?

Answer 8

Cholinesterase inhibitor ecothiopate, decreases pa in eye