Autonomic Nervous System drugs Flashcards
Sends impulses to the CNS
Afferent
Receives impulses, transmits through the spinal cord to effector organ cell
Efferent
Drugs act through receptors by binding to the receptors to initiate a response or prevent a response.
Receptor Theory
Drugs that produces a response
Agonist
Drugs that blocks a response
Antagonist
When Autonomic drugs are given, the goal is not to treat an autonomic disorder, it is to correct disorders of target organs through autonomic nerves
Pharmacologic effect
Has a catechol ring and amines
Catecholamines
Has no catechol ring
Non-catecholamines
Influences one type of receptor
Selective
Influences all receptor
Non-selective
An increase in the HR of 20 beats/minute or more from supine to standing indicates orthostatic hypotension
Orthostatic hypotension
Useful for treating mild to moderate hypertension, angina pectoris and myocardial infarction
Beta blockers
Is made from choline and acetyl CoA
Acetylcholine
Mimic the parasympathetic neurotransmitter acetylcholine
Cholinergic agonist
Not as susceptible to AChE, used locally to constrict pupil and decrease IOP
Carbachol