Autonomic Nervous System Drugs Flashcards
Drugs that affect the Autonomic Nervous System
Adrenergic Agonist
Adrenrgic Antagonist
Cholinergic Agonist
Cholinergic Antagonist
An Effect when Autonomic drugs are given, the goal is not to treat an autonomic disorder, it is to correct disorders of target organs through autonomic nerves.
Pharmacologic Effect
A type of ANS drug that stimulates adrenergic receptor
Sympathomimetics/ Adrenergic Agonist
3 Mechanism of Action of Adrenergic Agonists
Direct-acting sympathomimetic
Indirect-acting sympathomimetic
Mixed-acting sympathomimetic
Alpha 1 and Alpa 2 Receptors Treats what?
Alpha 1- Hypotension, Nasal congestion, dilation of pupils
Alpha 2- Hypertension
Beta 1 and Beta 2 Receptors Treats what
Beta 1- Heart Failure, cardiac arrest, shock
Beta 2- Asthma, premature labors of contraction
Adrenergenic Receptors of EPINEPHRINE and Its Therapeutic Use
Receptors: A1, A2, B1, B2
Therapeutic Use: Cardiac Arrest; asthma
Adrenergenic Receptors of PSEUDOEPHEDRINE; PHENYELPHRINE and Its Therapeutic Use
Receptoers: A1, B2
Therapeutic Use: Nasal decongestant
Adrenergic Receptor of ISOPROTERENOL and Its Therapeutic Use
Receptors: B1, B2
Therapeutic Use: Increase heart rate, force of contraction and conduction
Adrenergenic Receptor of DOBUTAMINE and Its Therapeutic Use
Receptor: B1
Therapeutic Use: Increases heart rate, force of contraction in heart failure, shock
Adrenergenic Receptor of ALBUTEROL and Its Therapeutic Use
Receptors: B2
Therapeutic Use: Asthma/ COPD
A type of ANS drug that Blocks alpha and beta receptor blockers
Adrenergic Antagonists
Adrenergic Antagonists Mechanism
- Direct Blocking by occupying receptors
- Indirect Blocking by inhibiting release of neurotransmitters
Give atleast 1 Adrenergenic Antagonist Drug that have A1 or A2 Receptor and Its therapeutic use
Phentolamine, Phenoxybenzamine (A1, A2), Hypertension
Prazosin, Terazosin (A1), Hypertension
Tamsulosin, Alfuzosin (A1), BPH- Urinary Relief
Give atleat 2 Adrenergenic Antagonist Drug that have B1 or B2 Receptor and Its Therapeutic use
Propanolol(1stgen) (B1,B2), Hypertension, Angina, Migraine
Timolol (1stgen) (B1,B2), Glaucoma, decrease intraocular pressure
Atenolol, Metoprolo (B1), Hypertension (2nd Gen- cardioselective)
Carvedilol, Labetalol (B1,B2), Hypertension- with Vasodilation
Pindolol (B1,B2), Decrease CO, HR for patients with heart block
A type of Drug that mimic the parasympathetic neurotransmitter acetylcholin
Cholinergic Agonist
Give 3 Direct and Indirect(Reversible) Acting Choligernic Agonists Drug
Direct Acting
- Acetylcholine
- Carbachol
- Pilocarpine
- Bethanechol
Indirect Acting
- Edrophonium
- Physostigmine
- Neostigmine
- Pyridostigmine
- Donepezil, Rivastigmine, Galantamne
Agents that bind Cholinoreceptors (muscarinic and nicotinic)
Cholinergic Antagonists
Give atleast 3 Anti-Muscalinic Agents
Atropine
Cyclopentolate, Tropicamide
Scopolamine
Ipratropium
Oxybutynin
Benztropine
Depolarizing Agent that causes sodium channels to open for prolonged depolarization
Succinylcholine
