Autonomic Nervous System drugs Flashcards
IT IS THE MASTER CONTROLLER OF THE BODY
Nervous System
AUTONOMIC NERVOUS SYSTEM
Responsible for involuntary controls
Consist of Sympathetic/Adrenergic and Parasympathetic/Cholinergic
WHAT IS SYNAPSE OR SYNAPTIC GAP?
Sets as a bridge or the one that sending the messages.
ALL PREGANGLIONIC NEUROTRNANSMITTER ARE ACTUALLY ____ FOR ALL SYMPATHETIC AND PARASYMPATHETIC.
Acetylcholine (ACh)
WHY PARASYMPATHETIC CALLED CHOLINERGIC?
Because the postganglionic transmitter in parasympathetic is Acetylcholine (ACh) as well.
THE STEPS OF SYNAPTIC TRANSMISSION
STEP 1: Synthesis of Neurotransmitter
STEP 2: Storage of Neurotransmitter
STEP 3: Release of Neurotransmitter
STEP 4: Action at the Receptor
STEP 5: Termination of Transmission
5a. Re-uptake
5b. Enzymatic degradation
5c. Diffusion away from the gap
THE PREGANGLIONS and POSTGANGLIONS OF SYMPATHETIC AND PARASYMPATHETIC
In SNS the shorter the preganglion, the longer of its postganglion however in PNS the postganglion is near the effector organs and it has longer preganglion.
IT IS A PHYSIOLOGICAL RESPONSES TO NON-IMMEDIATE STRESSES THAT ARE LARGELY THE SAME AS WHEN YOU ARE IN FIGHTING FOR SURVIVAL ( fight or flight)
Sympathetic Nervous System
ADRENERGIC AGONIST AND CHOLINERGIC ANTAGONIST PRODUCES WHAT?
Produces Sympathetic Nervous System (SNS) Effects
PHARMACOLOGIC EFFECT
The goal is not to treat an autonomic disorder, it is to correct disorders of target organs through autonomic nerves.
WHAT IS MIXED-ACTING SYMPATHOMIMETIC?
It has both direct and indirect sympathomimetic wherein it can directly enter the receptor site and increase the amount of Norepinephrine (NE)
AN INCREASE IN THE HEART RATE OF 20 beats/mins OR MORE FROM SUPINE TO STANDING INDICATES WHAT?
Orthostatic Hypotension
WHAT ARE THE RECEPTORS OF CHOLINERGIC AGONISTS?
Muscarinic and Nicotinic
THERAPEUTIC CLASS AND PHARMACOLOGIC CLASS OF BETHANICOL
Therapeutic class: Urinary Stimulants
Pharmacologic class: Cholinergic Agonists
WHAT IS MYASTHENIA GRAVIS?
An auto-immune disorder where there are generalized weakness. The patient has a problem on their ACh levels, to the extent that the patient may stop breathing because of the severe weakness.
ADVERSE REACTIONS FOR CHOLINERGIC AGONISTS
Diarrhea
Urination
Miosis or Muscle weakness
Bronchorrhea
Bradycardia
Emesis
Lacrimation
Salivation/Sweating
THE TEST THAT IS USED TO DIFFERENTIATE CHOLINERGIC CRISIS AND MYASTHENIC CRISIS
Tensilon Test
WHAT ARE THE NEURO-MUSCULAR BLOCKERS?
Non-depolarizing Agent and Depolarizing Agent
-DILATES PUPIL
-INCREASES HEART RATE
-CONSTRICTS BLOOD VESSELS
-RELAXES UTERINE MUSCLES
Sympathetic
THERAPEUTIC CLASS OF EPINEPHRINE
Vasopressor
ORIGIN OF SNS
Theracolumbar
ADRENERGIC BLOCKERS
Blocks Alpha and Beta receptor by Direct blocking (occupying receptors) and/or Indirect Blocking (inhibiting release of transmitters)
