Autonomic Nervous System Flashcards
autonomic system
involuntary system that controls smooth muscle, cardiac muscle, and gland function
somatic system
voluntary control (i.e. skeletal muscles)
ANS branches (x2): sympathetic
mobilises body during extreme situtations
ANS branches (x2): parasympathetic
allows the body to unwind and conserve energy
neurotransmitter
allows an impulse to pass across the gap or synapse from the neuron to the effector cell receptor
ANS neurotransmitters (x2): noradrenaline
binds to adrenergic receptors
ANS neurotransmitters (x2): acetylcholine (ACh)
binds to choline rigid receptors
sympathetic (adrenergic)
‘flight or fight’ system; stressed either physically or emotionally; suppresses non-vital bodily functions; promotes self-preservation; adrenergic receptors (alpha and beta receptors)
alpha 1 receptors
smooth muscle; peripheral blood vessels; urinary sphincter
alpha 2 receptors
‘controllers’ of neurotransmitter release; stimulation reduces the release of neurotransmitters
beta 1 receptors
located primarily in cardiac muscle and fatty tissue; stimulation increases heart rate and force of contraction
beta 2 receptors
located primarily in the bronchial smooth muscle; stimulation results in bronchodilation
adrenergic stimulation (‘flight or fight’)
allows the body to increase the rate and force of contraction of the heart; increase the ability of the respiratory tract to function; shunt blood to the major organs of the body; increase the formation of energy sources in the body
sympathomimetic medications
stimulate the sympathetic nervous system
sympatholytic medications
decrease the sympathetic response
agonist
medication capable of binding to receptors to initiate medication actions
antagonist
agent that blocks receptors stopping normal response
adrenergic agonists
mimic the action of the sympathetic nervous system neurotransmitters noradrenaline, adrenaline, and dopamine; these are called catecholamines
adrenergic agonists (alpha 1 receptors)
located primarily in smooth muscle tissue of the peripheral blood vessels; when stimulated (either by a neurotransmitter or medication), the smooth muscle contracts; increases blood pressure constriction
adrenergic agonists (beta 2 agonists)
produce bronchodilation when stimulated by adrenergic agents; known as bronchodilators; used in the treatment of asthma (e.g. salbutamol)
adrenergic agonists: geriatric considerations
more sensitive to the effects of adrenergic agonist medications; need close monitoring for excessive cardiac and CNS stimulation
sympatholytic medications
block or inhibit the responses of adrenergic neurotransmitters at alpha and beta receptor sites
alpha adrenergic blockers (alpha blockers)
inhibit the response at alpha receptors
beta adrenergic blockers (beta blockers)
compete with noradrenaline at available beta receptor sites
alpha blockers
cause vasodilation which decreases blood pressure; used to treat migraine headaches, hypertension, and peripheral vascular disease; prazosin [Minipress]
beta blockers
block the receptor sites in the heart; decreased pulse rate during both rest and exercise; lower BP and cause bronchoconstriction; treat hypertension, cardiac dysrhythmias, and angina
cholinergic pharmacology
medications that act on receptors that the neurotransmitter ACh binds to; ACh receptors are nicotine (sympathetic, parasympathetic, and somatic) and muscarinic (parasympathetic)
parasympathetic medications
parasympathetic action is generally directed at conserving energy, digestion, and elimination; major uses of muscarinic cholinergics are for diseases of the eyes, GI, and urinary systems
parasympathetic medications (anticholinergics)
act by blocking muscarinic receptors in the PNS; cause relaxation of smooth muscle in the bronchi resulting in bronchodilation; effective in the treatment of asthma and COPD; used for treatment of incontinence by increasing constriction of urinary sphincter; used for Parkinson’s by decreasing muscle rigidity and tremors
anticholinergics: side effects
blurred vision; dry mouth; constipation; urinary retention; tachycardia