Autonomic Agents Flashcards
Bethanechol
Cholinomimetic - Activates bowel and bladder
Carbachol
Cholinomimetic
Treats glaucoma causes pupillary constriction
Pilocarpine
Cholinomimetic
Constricts ciliary muscle of eye - Glaucoma
Stim. sweat, tears, saliva
Methacholine
Stimulates muscarinic R in airway when inhaled
Asthma challenge test
Neostigmine
Blocks AChE
Activates bowel/bladder
MG
Reverse NMJ blockade
Physostigmine
Blocks AChE - Anticholinergic Toxicity (CNS)
Donepezil, rivastigmine, galantamine
Blocks AChE - Alzheimers
Edrophonium
Blocks AChE - Historically dx MG
What side effects do you have to watch for when using cholinomimetics?
Exacerbation of COPD, asthma, and peptic ulcers in susceptible patients
What drug irreversibly inhibits AChE? What are the symptoms?
Organophosphates/Insecticides
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation, lacrimation, sweating, salivation
How do you treat organophosphate poisoning?
Atropine and Pralidoxime (regenerate AChE)
Atropine, homatropine, tropicamide
Muscarinic Antagonist
Mydriasis and cycloplegia
Benztropine
Muscarinic Antagonist - CNS
Parkinsons
Scopolamine
Muscarinic Antagonist - CNS
Motion sickness
Ipratropium & tiotropium
Muscarinic Antagonist - Respiratory
COPD and asthma