Autonomic Flashcards

1
Q

Where do parasympathetic pre ganglionic fibers originate?

A
  • CR III, VII, IX, & X

- In sacral segments

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2
Q

Where do sympathetic preganglionic fibers originate?

A

Thoracic & lumbar segments

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3
Q

Define: Adrenergic

A

Nerve ending that releases NE

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4
Q

Define: Adrencoceptor (adrenergic receptor)

A

Receptor that binds & is activated by 1 of the catecholamine transmitters/hormones

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5
Q

Define: Cholinergic

A

Nerve ending that releases acetylcholine

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6
Q

Define: Cholinoceptor (cholinergic receptor)

A

Receptor that binds & is activated by acetylcholine

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7
Q

Define: Postsynaptic receptor

A

Receptor located on distal side of a synapse

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8
Q

Define: Presynaptic receptor

A

Receptor located on the nerve ending from which the transmitter is released
- Modulates the release of transmitter

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9
Q

Define: Baroreceptor reflex

A

Neuronal homeostatic mechanism

- Maintains constant BP

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10
Q

Define: dopaminergic

A

Nerve ending that releases dopamine

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11
Q

Define: Homeostatic reflex

A

Compensatory mechanism for maintaining a body fxn at a predetermined level
- Ex. Baroreceptor reflex

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12
Q

Where is M1 located? & What is its fxn?

A
  • Nerve endings

- Increases IP3, DAG cascade

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13
Q

Where is M2 located? What is its fxn?

A
  • Heart, nerve endings

- Decreases cAMP, activated K channels

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14
Q

Where is M3 located? What is its fxn?

A
  • Effector cells, SM cells, glands, endothelium

- Increases IP3, DAG cascade

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15
Q

Where is a1 located? What is its fxn?

A
  • Effector tissues, SM, glands

- Increases Ca, causes contraction, secretion

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16
Q

Where is a2 located? What is its fxn?

A
  • Nerve endings, SM

- Decreases transmitter release, causes contraction

17
Q

Where is β1 located? What is its fxn?

A
  • Cardiac muscle, juxtaglomerular apparatus

- Increases HR, force, & renin release

18
Q

Where is β2 located? What is its fxn?

A
  • SM, liver, heart
  • Relaxes SM
  • Increases glycogenolysis & HR
  • Force
19
Q

Where is β3 located? What is its fxn?

A
  • Adipose cells

- Increases lipolysis

20
Q

Where is D1 located? What is its fxn?

A
  • SM

- Relaxes renal SM

21
Q

What receptors are involved in the ciliary muscle? What do they do?

A
  • Sympathetic: β relaxes

- Parasympathetic: M3 contracts

22
Q

What receptors are involved in the SA node? What do they do?

A
  • Sympathetic: β1 & β2 accelerates

- Parasympathetic: M2 decelerates

23
Q

What receptors are involved in contractility of the heart? What do they do?

A
  • Sympathetic: β1 & β2 increases

- Parasympathetic: M2 decreases

24
Q

What receptor is involved in the myenteric plexus (GI)? What does it do?

A

Parasympathetic: M1 activates

25
Q

What receptors are involved in the liver? What is their action?

A

β2, a

Sympathetic: Gluconeogenesis

26
Q

What receptor is involved in the kidney & what is its action?

A

β1

Sympathetic: Renin release

27
Q

What receptors are involved in the bronchiolar SM? What are their actions?

A

β2: Sympathetic, relaxes

M3: Parasympathetic, contracts

28
Q

What is the action of local anesthetics?

A

Block: Na channels & conduction

29
Q

What is the action of Reserpine?

A

Prevents storage, depletes

30
Q

What is the action of amphetamines?

A

Promote release

31
Q

What is the action of cocaine & tricyclic antidepressants?

A

Inhibit uptake, increase transmitter effect on postsynaptic receptors

32
Q

What is the action of Propranolol?

A

Binds β receptors; prevents activation

33
Q

What is the action of Nicotine?

A

Binds nicotinic receptors; opens ion channel in post-synaptic mem

34
Q

What is the action of Bethanechol

A

Binds & activates muscarinic receptors

35
Q

What is the action of Neostigmine?

A

Inhibits enzyme; prolongs & intensifies transmitter action