Autoimmunity & Related Disorders

Question 1

What is known as the body’s immune system becoming misdirected and attacking organs it was designed to protect?

Answer 1

Autoimmunity

Question 2

What do autoimmune disorders represent?

Answer 2

Fourth largest cause of disability in Europe and the US

Question 3

What displays specificity for self antigens?

Answer 3

Immunoglobulins (Autoantibodies)
Cytotoxic T cells

Question 4

What happens in regards to antibodies and self antigens when functions are NOT working properly?

Answer 4

Bind to antigens in circulation
Form Circulating Immune Complexes

Question 5

What occurs 10 - 15 times more likely in women than in men?

Answer 5

Systemic Lupus Erythematosus (SLE)

Question 6

What do SLE patients suffer from accounting for a leading cause of death?

Answer 6

Progressive renal disease
CNS disease

Question 7

What is the hallmark autoantibody of SLE?

Answer 7

Antinuclear Antibody

Question 8

What are antibodies directed against in patients with SLE?

Answer 8

Cardiolipin
Associated with Arterial/Venous Thrombosis

Question 9

Who has a significantly higher chance of Rheumatoid Arthritis (RH)?

Answer 9

Persons with HLA-DR4 Haplotype

Question 10

What percentage of adults with RH have IgM Rheumatoid factor?

Answer 10

70%

Question 11

What percentage of RA patients have Antinuclear Antibodies?

Answer 11

14% - 28% of RA patients
Lower titers than SLE

Question 12

Where do we find the Major Histocompatibility Complex (MHC)?

Answer 12

Chromosome 6, Band 21 (6p21)

Question 13

What is common after allogeneic bone marrow or hematopoietic progenitor cell transplantation?

Answer 13

Graft-versus-host Disease
Affects Skin, Liver, Gut