Autoimmunity and related disorders Flashcards
What happens during autoimmunity?
the body’s immune system becomes misdirected and attacks organs it was designed to protect
what represents the fourth largest cause of disability in europe and united states?
autoimmune disorders
what happens when autoimmune disease causes the immune systems functions to fail?
antibodies are produced and bind to antigens in the circulation to form immune complexes
how does lupus affect women?
occurs 10 to 15 times more frequently in women
what is the leading cause of death in hospitalized patients suffering from progressive renal disease or cns disease?
Systemic Lupus Erythematosus infections
what are the most common SLE infections?
bacterial, fungal, viral, and parasitic
who produces multiple autoantibodies?
patients with SLE
what is the hallmark autoantibody of SLE?
antinuclear antibodies. these include histone, and non histone protein antibodies
who has a significantly higher incidence of RA?
HLA-DR4 haplotype
immunoglobulin M rheumatoid factor is manifested in how many adults with RA?
70% of adults
What is demonstrated in 14 to 28% of RA patients?
Antinuclear Antibodies
does RA or SLE have a lower titer of antinuclear antibodies?
RA has a lower titer
Where is MHC found?
chromosome 6 at band 21
Graft vs Host disease is a syndrome which mainly affects what?
skin, liver and gut
what is common after allogeneic bone marrow or hematopoietic progenitor cell transplantation?
Graft vs Host disease
