Autoimmunity Flashcards
MAKAPASAG MIDTERM
An expression of the immune response that occurs when the body’s self-tolerance system fails
Autoimmunity
Htper immunoglobulin E that would stimulate skin infections and abscesses
Job syndrome
5 Possible staining patterns
Homogenous Speckled Peripheral Nucleolar Anti-centromere
Super-clean pattern
Homogenous
Super-clean pattern
Homogenous
Dalmatian spotted pattern
Speckled
Dark rim around the periphery
Peripheral
Dark large spot at the center
Nucleolar
Referring to chromatin / chromatin strands
Anti-centromere
Associated antibody
For homogenous pattern
nDNA dsDNA ssDNA DNP Histones
Associated antibody
For speckled pattern
RNP
Sm
Associated antibody
For peripheral pattern
nDNA
dsDNA
DNP
Associated antibody
For nucleolar pattern
Nucleolar RNA
Associated antibody
For Anti-centromere pattern
Centromeric Chromatin
Associsted disease
For homogenous pattern
RA
SLE
Sjorgen’s syndrome
Associsted disease
For speckled pattern
Scleroderma RA Sjogren's syndrome SLE Dermatomyositis
Associated disease
For Peripheral pattern
Sjogren’s syndrome
SLE
Associated disease
For nucleolar pattern
Scleroderma
Sjogren’s syndrome
SLE
Associated disease
For anti-centromere pattern
Scleroderma
Associated Antibodies
Of SLE
Anti-DNA
Antinuclear
Antiribosome
Anti-DNP
Associated Antibodies
Of primary biliary cirrhosis
Antimitochondrial
Associated Antibodies
Of myasthenia gravis
Antiacetylcholine receptor binding
Antiacetylcholine receptor blocking
Associated Antibodies
Of pernicious anemia
Anti-intrinsic factor
Antiparietal cells
Associated Antibodies
Of multiple sclerosis
Antimyelin
Associated Antibodies
Of scleroderma
Anticentriole
Anti-Scl
Associated Antibodies
Of sjogren’s syndrome
Anti-SS-A
Antii-SS-B
Associated Antibodies
Of graves’ disease
Antithyroglobulin
Associated Antibodies
Of polymyositis
Anti-Jo-1
Anti-Ku
Anti-Mi-1
Anti-PM-1
Associated Antibodies
Of goodpasture’s syndrome
Antiglomerular basement
Associated Antibodies
Of ITP
Antiplatelet
Associated Antibodies
Insulin-dependent diabetes
Anti-islet cell
If a chemotaxin is inefficient the its phagocytosis is inefficient
Tuftsin deficiency
Protein present in cytoskeletal muscle
Actin dysfunction
Become denatured or mutated because of physical, chemical, or biological changes
Altered antigens
Which may become responsive to self-antigens
Mutation of immunocompetent cells
Which may lose their ability to regulate the immune response
Dysfunction of T cells
Presence of abnormal circulating IgM autoantibodies known collectively as rheumatoid factor. React with the fc portion of Igg molecules
Rheumatoid athritis
Characterized by inflammation and degeneration of skeletal muscle
Polymyositis
Systemic rheumatoid disorder that is characterized by the presence of circulating immune complexes
SLE
Autoantibodies that react with the body’s nuclear proteins, DNA, or histones
Anti-nuclear antibody (ANA)
Thymus gland develops abnormally
T lymphocytes are usually decreased
High CD4 : CD 8 RATIO
DiGeorge syndrome
Autosomal recessive disorder
Patients are athymic(absnece of thymus)
Susceptible to viral and fungal infections
Nezelof syndrome
