Autoimmunity

Question 1

An expression of the immune response that occurs when the body’s self-tolerance system fails

Answer 1

Autoimmunity

Question 2

Htper immunoglobulin E that would stimulate skin infections and abscesses

Answer 2

Job syndrome

Question 3

5 Possible staining patterns

Answer 3

Homogenous
Speckled
Peripheral
Nucleolar
Anti-centromere

Question 4

Super-clean pattern

Answer 4

Homogenous

Question 5

Super-clean pattern

Answer 5

Homogenous

Question 6

Dalmatian spotted pattern

Answer 6

Speckled

Question 7

Dark rim around the periphery

Answer 7

Peripheral

Question 8

Dark large spot at the center

Answer 8

Nucleolar

Question 9

Referring to chromatin / chromatin strands

Answer 9

Anti-centromere

Question 10

Associated antibody

For homogenous pattern

Answer 10

nDNA
dsDNA
ssDNA
DNP
Histones

Question 11

Associated antibody

For speckled pattern

Answer 11

RNP

Sm

Question 12

Associated antibody

For peripheral pattern

Answer 12

nDNA
dsDNA
DNP

Question 13

Associated antibody

For nucleolar pattern

Answer 13

Nucleolar RNA

Question 14

Associated antibody

For Anti-centromere pattern

Answer 14

Centromeric Chromatin

Question 15

Associsted disease

For homogenous pattern

Answer 15

RA
SLE
Sjorgen’s syndrome

Question 16

Associsted disease

For speckled pattern

Answer 16

Scleroderma
RA
Sjogren's syndrome
SLE
Dermatomyositis

Question 17

Associated disease

For Peripheral pattern

Answer 17

Sjogren’s syndrome

SLE

Question 18

Associated disease

For nucleolar pattern

Answer 18

Scleroderma
Sjogren’s syndrome
SLE

Question 19

Associated disease

For anti-centromere pattern

Answer 19

Scleroderma

Question 20

Associated Antibodies

Of SLE

Answer 20

Anti-DNA
Antinuclear
Antiribosome
Anti-DNP

Question 21

Associated Antibodies

Of primary biliary cirrhosis

Answer 21

Antimitochondrial

Question 22

Associated Antibodies

Of myasthenia gravis

Answer 22

Antiacetylcholine receptor binding

Antiacetylcholine receptor blocking

Question 23

Associated Antibodies

Of pernicious anemia

Answer 23

Anti-intrinsic factor

Antiparietal cells

Question 24

Associated Antibodies

Of multiple sclerosis

Answer 24

Antimyelin

Question 25

Associated Antibodies

Of scleroderma

Answer 25

Anticentriole

Anti-Scl

Question 26

Associated Antibodies

Of sjogren’s syndrome

Answer 26

Anti-SS-A

Antii-SS-B

Question 27

Associated Antibodies

Of graves’ disease

Answer 27

Antithyroglobulin

Question 28

Associated Antibodies

Of polymyositis

Answer 28

Anti-Jo-1
Anti-Ku
Anti-Mi-1
Anti-PM-1

Question 29

Associated Antibodies

Of goodpasture’s syndrome

Answer 29

Antiglomerular basement

Question 30

Associated Antibodies

Of ITP

Answer 30

Antiplatelet

Question 31

Associated Antibodies

Insulin-dependent diabetes

Answer 31

Anti-islet cell

Question 32

If a chemotaxin is inefficient the its phagocytosis is inefficient

Answer 32

Tuftsin deficiency

Question 33

Protein present in cytoskeletal muscle

Answer 33

Actin dysfunction

Question 34

Become denatured or mutated because of physical, chemical, or biological changes

Answer 34

Altered antigens

Question 35

Which may become responsive to self-antigens

Answer 35

Mutation of immunocompetent cells

Question 36

Which may lose their ability to regulate the immune response

Answer 36

Dysfunction of T cells

Question 37

Presence of abnormal circulating IgM autoantibodies known collectively as rheumatoid factor. React with the fc portion of Igg molecules

Answer 37

Rheumatoid athritis

Question 38

Characterized by inflammation and degeneration of skeletal muscle

Answer 38

Polymyositis

Question 39

Systemic rheumatoid disorder that is characterized by the presence of circulating immune complexes

Answer 39

SLE

Question 40

Autoantibodies that react with the body’s nuclear proteins, DNA, or histones

Answer 40

Anti-nuclear antibody (ANA)

Question 41

Thymus gland develops abnormally

T lymphocytes are usually decreased

High CD4 : CD 8 RATIO

Answer 41

DiGeorge syndrome

Question 42

Autosomal recessive disorder

Patients are athymic(absnece of thymus)

Susceptible to viral and fungal infections

Answer 42

Nezelof syndrome