Autoimmunity

Question 1

Goodpasture’s Syndrome

Primary Pathology initiated by, Antigen, Antibodies, Characteristic features, Investigations, Mechanism of Pathology

Answer 1

• Primary Pathology: Antibody to cell surface antigen
• Antogen: Glomerular Basement Membrane (GBM)
• Antibodies: Anti-GBM antibody
• Characterirst features: Lung (Alveloar) & Kidney
  Linear deposition of IgG & Complement
• Inverstigation: Anti-GBM antibodies
• Mechanism of Pathology: Pathology manifests as Type II hypersensitivity immune responses

Question 2

Cold Agglutinin Disease

Primary Pathology initiated by, Antigen, Antibodies, Characteristic features, Investigations

Mechanism of Pathology

Answer 2

• Primary Pathology Initiated: Antibody to cell surface antigen
• Antigien: Glycophorin (Ii)
• Antibodies: Anti-glycophorin Ab (Anti-Ii antibody)
• Chracterisitc features: Anemia
• Investigation: Agglutination on blood smear
• Mechanism of P: Complement fixation – IgM antibodies.

Question 3

Pernicious Anemia

Primary Pathology initiated by

Antigen

Antibodies

Characteristic features

Investigations

Mechanism of Pathology

Answer 3

• PPI: Antibody to cell surface antigen
• Antigen:Gastric parietal cell antigen H+/K+ ATPase
• Antibodies: Anti-parietal cell H+/K+ ATPase Ab.
• Chracteristic features: Defective red blood cells: megablastic anemia

Serum B12

Destruction of parietal cells that secrete intrinsic factor