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Immunology and Serology > Autoimmunity > Flashcards

Autoimmunity Flashcards

1
Q

Individuals who possesses this allele has a greater chance of developing the disease.

A

HLAB27

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2
Q

When you are infected with any microorganisms that would carry antigens that have similar antigens with our normal cells.

A

Molecular mimicry

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3
Q

A systemic autoimmune disease that exhibits wolf-life butterfly rash and diffuse proliferative glomerulonephritis.

A

Systemic Lupus Erythematosus

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4
Q

A neutrophil that is engulfed by an Ab-coated nucleus of another neutrophil.

A

Lupus erythematosus cell

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5
Q
  • an important immunological marker of SLE.
  • antibody that reacts to the nucleus of the cells
A

Autoantinuclear antibody (ANA)

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6
Q

Gold standard for detecting ANA

A

Fluorescent antinuclear Ab (FANA) testing

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7
Q

Identify the fluorescent pattern in FANA test.
- Also known as diffuse
- Uniform staining of entire nucleus
- Found in patients with SLE

A

Homegenous

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8
Q

Identify the fluorescent pattern in FANA test.
- Greater staining intensity
- Strong staining of condensed chromatin
- Highly specific for SLE patients

A

Peripheral

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9
Q

Identify the fluorescent pattern in FANA test.
- Discrete, fluorescent specks
- Staining is absent in nucleolus and chromatin of dividing cells

A

Speckled

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10
Q

Identify the fluorescent pattern in FANA test.
- Prominent staining of the nucleolar
- Associated antibodies to RNA and RNP
- In patients with scleroderma and other connective tissue diseases

A

Nucleolar

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11
Q

Identify ANA.
- Most specific for SLE

A

anti-dsDNA

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12
Q

Identify ANA.
- Diagnostic for SLE

A

anti-sm

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13
Q

Identify ANA.
- Related to purines and pyrimidines

A

Anti-ssDNA

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14
Q

A systemic autoimmune disease that is present in joints and bones.

A

Rheumatoid arthritis

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15
Q

A systemic autoimmune disease that is present in upper respiratory system, lungs, and blood vessels.

A

Granulomatosis (Wegener’s granulomatosis)

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16
Q

A systemic autoimmune disease that is present in multiple cells throughout the body.

A

Systemic Lupus Erythematosus

17
Q

Autoantibodies to cyclic citrullinated peptides (for rheumatoid arthritis)

A

Anti-CCP

18
Q

What is the most common autoimmune thyroid disease in the US?

A

Grave’s disease

19
Q

The inflammatory autoimmune disorder of the central nervous system.

A

Multiple sclerosis

20
Q

An organ-specific autoimmune disease that affects the nerve-muscle synapses.

A

Myasthenia gravis

21
Q

An organ-specific autoimmune disease that affects the kidneys and lungs.

A

Goodpasture’s syndrome

Immunology and Serology (1 decks)

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