Autoimmune Hemolytic Anemias Flashcards
How many RBCs are produced during compensation?
Almost equal the amount that is getting destroyed
How does Hemolytic anemia appear in a blood smear?
Macrocytosis
Spherocytosis
> 3% reticulocyte
How can Auto Immune Hemolytic Anemia (AIHA) be diagnosed/classified?
Cold Reactive
Warm Reactive
Drug Induced
What are cold antibodies that can activate complement in vitro?
IgM Immunoglobulins
What can happen if an individuals RBCs are coated with cold agglutinins?
Direct Agglutination
False positives
If a patient has benign cold agglutinins, what result do we see on their DAT?
Negative
What is the most commonly encountered cold autoantibody?
Auto anti-I
What can i adults also produce?
Alloanti - I
What can Cold Hemagglutinin Disease (Idiopathic Cold AIHA) often be associated with?
Mycoplasma Pneumoniae or Mono
What specific antibody do we typically see in a clinical picture disorder?
Anti - I
What can occur in children who have had measles, mumps, chickenpox, mono, and/or flu?
Paroxysmal Cold Hemoglobinuria
What kind of antibody reacts best at 37C and accounts for about 70% of reported AIHA cases?
Warm Autoantibodies
What kind of anemia do we see the antibody only reacting with RBCs in the presence of a drug?
Drug Induced Immune Hemolytic Anemia (DIIHA)
What is the function of Alpha Methydopa?
Induces the productions of autoantibody that recognizes RBC antigens
What alters the function of T-suppressor cells and allows the production of antibodies against self?
Methyldopa
What do we find on the blood smear of Warm Auto Immune Hemolytic Anemia (WAIHA)?
Polychromasia
Macrocytosis
Reticulocytosis
NRBCs
When RBCs are sensitized with IgG causing destruction, where does this take place?
Primarily Extravascularly
Aside from using monoclonal antisera to determine the patients RBC phenotype, what is another way we can find it?
Treating RBCs with Chloroquine diphosphate to remove IgG coating
