Autoimmune Diseases and Correlating Antibodies Flashcards

1
Q

Abs to spliceosomal snRNPs (anti-Smith Abs)

A

SLE

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2
Q

Anti-U1 RNP Abs

A

mixed connective tissue diseases

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3
Q

Ab to phospholipase A2 receptors in nephron

A

membranous nephropathy

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4
Q

N-myc oncogene

A

Neuroblastoma

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5
Q

MEN 1 gene (tumor suppressor gene)

A

MEN 1

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6
Q

Ret gene (oncogene)

A

MEN 2A and MEN 2B

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7
Q

Autoantibodies to adrenal glands

A

Addison Disease

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8
Q

Anti-TSH Abs

A

Graves Disease

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9
Q

HLA-DR3 and HLA-B8

A

Graves Disease

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10
Q

HLA - B35

A

Subacute Thyroiditis

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11
Q

anti-peroxidase (antimicrosomal) Abs

A

Hashimoto thyroiditis

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12
Q

antithyroglobulin Abs

A

Hashimoto thyroiditis

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13
Q

HLA-DR5

A

Hashimoto thyroiditis

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14
Q

RET oncogene, NTRK1, or BRAF mutations

A

Papillary Carcinoma

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15
Q

RET gene mutation

A

Medullary Thyroid Carcinoma

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16
Q

PAX8- PPARgamma-1 rearrangement or RAS mutation

A

Follicular Thyroid Carcinoma

17
Q

HLA-DR3 and HLA-DR4

A

Type 1 Diabetes

18
Q

Anti-mitochondrial Ab

A

Primary Biliary Cirrhosis

19
Q

60 y/o woman, RA, no alcohol history, fatigue and right abdominal pain; elevated ANA and ASMA, elevated serum IgG levels, no viral serologic markers

A

autoimmune hepatitis

20
Q

23 yo woman, no alcohol history; elevated levels of LKM-1 Abs, no viral serologic markers, liver biopsy with infiltration of the portal and periportal area with lymphocytes

A

autoimmune hepatitis