Autoimmune Diseases and Correlating Antibodies

Question 1

Abs to spliceosomal snRNPs (anti-Smith Abs)

Answer 1

SLE

Question 2

Anti-U1 RNP Abs

Answer 2

mixed connective tissue diseases

Question 3

Ab to phospholipase A2 receptors in nephron

Answer 3

membranous nephropathy

Question 4

N-myc oncogene

Answer 4

Neuroblastoma

Question 5

MEN 1 gene (tumor suppressor gene)

Answer 5

MEN 1

Question 6

Ret gene (oncogene)

Answer 6

MEN 2A and MEN 2B

Question 7

Autoantibodies to adrenal glands

Answer 7

Addison Disease

Question 8

Anti-TSH Abs

Answer 8

Graves Disease

Question 9

HLA-DR3 and HLA-B8

Answer 9

Graves Disease

Question 10

HLA - B35

Answer 10

Subacute Thyroiditis

Question 11

anti-peroxidase (antimicrosomal) Abs

Answer 11

Hashimoto thyroiditis

Question 12

antithyroglobulin Abs

Answer 12

Hashimoto thyroiditis

Question 13

HLA-DR5

Answer 13

Hashimoto thyroiditis

Question 14

RET oncogene, NTRK1, or BRAF mutations

Answer 14

Papillary Carcinoma

Question 15

RET gene mutation

Answer 15

Medullary Thyroid Carcinoma

Question 16

PAX8- PPARgamma-1 rearrangement or RAS mutation

Answer 16

Follicular Thyroid Carcinoma

Question 17

HLA-DR3 and HLA-DR4

Answer 17

Type 1 Diabetes

Question 18

Anti-mitochondrial Ab

Answer 18

Primary Biliary Cirrhosis

Question 19

60 y/o woman, RA, no alcohol history, fatigue and right abdominal pain; elevated ANA and ASMA, elevated serum IgG levels, no viral serologic markers

Answer 19

autoimmune hepatitis

Question 20

23 yo woman, no alcohol history; elevated levels of LKM-1 Abs, no viral serologic markers, liver biopsy with infiltration of the portal and periportal area with lymphocytes

Answer 20

autoimmune hepatitis