Autoimmune diseases

Question 1

what is the most common autoimmune diseases in dogs and cats?

Answer 1

Pemphigus Foliaceus

Question 2

What desmosome target is present for pemphigus foliaceus?

Answer 2

Desmocollin 1

Question 3

Where are lesions found for pemphigus foliaceus?

Answer 3

Lesions are localized to the head, face and ears in most cases.

Question 4

How do you diagnose Pemphigus foliaceus

Answer 4

biopsy of a pustule is necessary for diagnosis. If there is not a pustule then use thickened crust.

Question 5

What is the treatment protocol for PF?

Answer 5

Immunosuppression

Prednisone 2-4mg/kg/day in dogs 4-8mg/kg/day in a cat

Cyclosporine 7-10mg/kg/day

Mycophenolate mofetil 20-40mg/kg/day divided into 3 doses

Azithioprine 1.5-2.5mg/kg/day until remission

Question 6

Where are Pemphigus erythematosus lesions found

Answer 6

symetrical crusting of the nose, face, and ears with subsuquent ulcerations.