autoimmune disease

Question 1

Graves’ disease

Answer 1

hyperthyroidism and excess hormones
Ab binds to receptor and mimics natural ligand
type II

Question 2

Goodpasture’s syndrome

Answer 2

Ab attack collagen in kidney -> kidney failure

type II

Question 3

Myasthenia gravis

Answer 3

progressive muscle weakness
Ab reactive to ACH receptors at NMJ preventing signal transmission
type ii

Question 4

Hemolytic disease of fetus - erythroblastosis fetalis.

Answer 4

Maternal IgG Ab specific for fetal blood (Rh antigen) cross placenta and kill fetal RBC
type ii

Question 5

thrombocytopenic purpura

Answer 5

Ab against platelet surface antigens

type ii

Question 6

SLE

Answer 6

most prevalent in developed countries.
Have Ab for autoantigens.
IC trapped in kidneys and synovial tissue joints
type iii

Question 7

PSGN

Answer 7

post 1-3 weeks strep. Due to strep antigen + anti-strep Ab deposits in glomerulus
type iii

Question 8

Serum sickness

Answer 8

lots antigen/ab complex from IV bolus soluble antigen.
Chronic infection microbes can also cause from making soluble proteins
type iii

Question 9

arthus reaction

Answer 9

IgG Ab against antigen -> injection antigen in skin cause mast cell activation and formation of immune complex hours after (looks like wheal and flare)
type iii

Question 10

Poison ivy

Answer 10

pentadecatechol cross cell membrane -> modify host self-antigen -> make new epitope -> presented to MHC I to CD8
type iv

Question 11

tuberculin test

Answer 11

inject PPD into individual -> T cell mediated response -> 24-48hrs local swelling -> tissue destruction
type iv

Question 12

Celiac disease

Answer 12

AI of small intestine. CD4 respond to peptides in gluten