Autoimmune Disease Flashcards
Physiology of Autoimmunity Prevention.
During B/T cell Development, there is usually a process of selection whereby cells reactive to self antigens are eliminated or kept in check (self-tolerance).
Aetiology of Autoimmunity.
- Breakdown of mechanisms that maintain self-tolerance = activation of self-reactive clones of B/T cells.
- Generation of autoantibodies and/or cell-mediated responses to self-antigens.
What is Autoimmune Disease?
Humoral and/or Cell-Mediated Responses to self-antigens associated with pathological changes.
Investigation of Autoimmune Serology.
Identification and measurement of serum autoantibodies for diagnostic purposes e.g. ANA.
Which antibodies are associate with Coeliac Disease?
- IgA EMA Antibodies.
2. IgA tTG Antibodies.
Which antibodies are associated with Atrophic Gastritis?
Anti-Gastric Parietal Cell Antibodies.
Which antibodies are associated with Pernicious Anaemia? (2)
- Anti-Gastric Parietal Cell Antibodies.
2. Anti-Intrinsic Factor Antibodies.
Which antibodies are associated with Primary Biliary Cirrhosis? (2)
- Anti-Mitochondrial Antibodies.
2. Anti-PDH (M2) Antibodies.
Which antibodies are associated with Autoimmune Hepatitis?
Anti-Smooth Muscle Antibodies.
Which antibodies are associated with Goodpasture’s Syndrome?
Anti-GBM (Glomerular Basement Membrane) Antibodies.
Which antibodies are associated with GPA (Granulomatosis with Polyangiitis / Wegener’s) and EGPA (Eosinophilic / Churg-Strauss’)?
Anti-PR3 (c-ANCA) Antibodies.
Which antibodies are associated with Microscopic Polyangiitis, Crescenteric Glomerulonephritis, EGPA?
Anti-MPO (p-ANCA) Antibodies.
Which antibodies are associated with Anti-Phospholipid Syndrome?
Anti-Cardiolipin Antibodies.
Which antibodies are associated with Autoimmune Bullous Skin Disease (Pemphigus/Pemphigoid)?
Anti-Skin Antibodies.
Which antibodies are associated with Addison’s disease?
Anti-Adrenocortical Antibodies.
