Autoimmune Disease - Cryoglobulinaemia Flashcards
1
Q
What is Cryoglobulinaemia?
A
Immunoglobulins undergoing reversible precipitation at 4 Degrees, dissolving when warmed to 37 Degrees.
2
Q
What is Type I Cryoglobulinaemia?
A
Monoclonal - IgG/IgM.
3
Q
What is Type I Cryoglobulinaemia associated with? (2)
A
- Multiple Myeloma.
2. Waldenstrom’s Macroglobulinaemia.
4
Q
What is Type II Cryoglobulinaemia?
A
Mixed Monoclonal and Polyclonal with RF.
5
Q
What is Type II Cryoglobulinaemia associated with? (4)
A
- Hepatitis C.
- Rheumatoid Arthritis.
- Sjogren’s.
- Lymphoma.
6
Q
What is Type III Cryoglobulinaemia?
A
Polyclonal with RF.
7
Q
What is Type II Cryoglobulinaemia associated with?
A
- Rheumatoid Arthritis.
2. Sjogren’s.
8
Q
Clinical Presentation of Cryoglobulinaemia (3).
A
- Vascular Purpura, Distal Ulceration.
- Arthralgia.
- Renal : Diffuse Glomerulonephritis.
9
Q
Bloods in Cryoglobulinaemia.
A
- Low Complement - C4.
2. High ESR.
10
Q
Management of Cryoglobulinaemia.
A
- Immunosuppression.
2. Plasmapheresis.
