Autoimmune + Alcohol

Question 1

Vasculitis is characterized by

Answer 1

inflammation of blood vessels, leading to tissue damage and necrosis.

Question 2

Vasculitis treatment

Answer 2

Glucocorticoids are the initial therapy.
(prednisone, 1–2 mg/kg/d).

Question 3

Necrotizing vasculitis when major organ system involvement is present-______________initial drug of choice.

Answer 3

Cyclophosphamide

Question 4

Vasculitis in SLE or RA treatment

Answer 4

• Prednisone 60-80 mg/d, Cyclophosphamide 1-2mg/kg/d can be added

Question 5

SLE diagnosis

Answer 5

D- discoid rash (flat w/ pronounced red borders)
O-oral ulcers (painless)
P-photosensitive rash
A-arthralgias/arthritis
M- Malar rash (“facial butterfly” over facial bridge and nose)
I- immunological phenomenon (anti-SM,anti-dsDNA, Anti-RO, Anti-LA, anti-histone)
NE- neurological phenomenon (AMS, seizures, stroke, HA)

R- renal involvement (nephritic or nephrotic disorder)
A-ANA positive (not sensitive)
S- serositis (pleuritis, pericarditis, peritonitis)
H- heme phenomenon (anemia, thrombocytopenia, hemolytic anemia)

Question 6

treatment of SLW

Answer 6

Stop smoking
Frequent labs (CBC, ESR, CRP)
NSAIDs
Hydroxychloroquine
Systemic corticosteroids
Methotrexate, cyclophosphamide, Azathioprine

Question 7

ETOH Withdrawal- occurs in heavy drinkers due to an imbalance of

Answer 7

GABA and excitatory glutamate causing hyperactive alcohol withdrawal

Question 8

Identification of risk factors for severe withdrawal -

Answer 8

onset of symptoms upon waking, severe past withdrawals, concomitant substance abuse and medical or psych conditions

Question 9

Treatment of ETOH Withdrawal

Answer 9

CTH w/o contrast- for focal deficits, seizures, deteriorating LOC, trauma
RUQ US
CXR - for fever to r/o aspiration
Lumbar puncture?