Autoimmune

Question 1

define Immunologic tolerance

Answer 1

unresponsiveness to an antigen that is induced by

previous exposure to that antigen

Question 2

How does to immune system normally avoid autoimmune disease

Answer 2

the T and B cells bearing self-reactive molecules
must be eliminated or downregulated.

Central and peripheral tolerance

Question 3

What is central tolerance

Answer 3

The thymus plays an important role in eliminating T cells with high affinity
to self-antigens
• Bone marrow is important in B cell tolerance

Question 4

What is peripheral tolerance

Answer 4

Peripheral tolerance
• Mature lymphocytes that recognize self antigens in peripheral tissues become
incapable of activation or die by apoptosis