Autocoids I

Question 1

Chlorpheniramine, diphenhydramine, pyrilamine, cyclizine, promethazine, cyproheptadine

Answer 1

first generation H1 antagonists
Pharm: cross BBB and cause sedation
- less selectivity
- block H1 receptor
Side effect:
sedation, anticholinoceptor action, orthostatic hypotension
Uses: motion sickness, antiparkinsonism effect, antiadrenoceptor action, asthma treatment, allergic response, cough preparation, meniere’s disease

Question 2

fexofenadine, loratadine, cetirizine, acrivastine

Answer 2

H1 antagonists, 2nd generation
Pharm: does not cross BBB, no sedation
Side effects: less sedation, less effective

Question 3

reserpine

Answer 3

depletion of serotonin

Question 4

buspirone

Answer 4

anxiolytic, 5HT1a agonist

Uses: generalized anxiety disorders

Question 5

sumatriptan

Answer 5

5HT1d/1b agonist

Uses: migraine

Question 6

cisapride

Answer 6

5HT4 agonist

Uses: treatment of GERD

Question 7

cyproheptadine

Answer 7

Pharm: serotonin antagonist
Uses: postgastrectomy dump syndrome

Question 8

ritaserine

Answer 8

Inhibition of 5HT2 receptor, reduce thromboxane formation
- block dopamine uptake
Uses: schizo, cyclical vomiting, smooth muscle treatment of carcinoid tumor

Question 9

ondansetron

Answer 9

5HT3 antagonist

Uses: GI side effects due to CA chemo

Question 10

Ketaserin

Answer 10

5HT2 block, alpha 1 adrenergic receptor

Uses: HTN in europe