Autocoids Flashcards
What drug is an H2 antagonist?
Cimetidine
Ranitidine
True or false, H4 is found on the bone marrow and white blood cells?
True
True or false, tissue damage cannot activate kallikrein-kininogen-kinin system?
False
What are the function of 5-HT?
Central chemical transmitter for tryptaminergic neurons of the brain
Regulation of GI motility and presitalsis
Precursor of melatonin
True or false, 5-HT4 agonist-cisapride-anxiety or depression?
False; Cisapride is for GI motility and peristalsis
Gastrointestinal bleeding from aspirin is considered a?
Side effect
What are the autocoids involved in inflammatory reaction?
Histamine
Bradykinin
Serotonin
Prostanoids
What are the physiologic effects mediated by histamine?
Vasodilation
Increased vascular permeability
Stimuation of sensory nerve endings
Traditional H1 blockers have the following effects?
Promote sedation
Relieve allergic manifestations on the skin and mucous membrane
Emesis
What drug is least sedating: loratadine, chlorpenamine, diphenhydramine and clemastine?
Loratadine; It does not cross the blood brain barrier.
What are the therapeutic uses of H1 blockers?
Aid in sleeping
Countering motion sickness
Relieve itching and rashes in allergic disease
What body functions involve 5-HT?
Fertility
Feeding
Sleeping
Mentation
What enzyme class is responsible for converting tryptophan to serotonin?
Hydroxylase
Decarboxylase
Prostanoids have the following clinical significance?
Platelet function
Inflammatory reaction
Reproduction
What enzymes are inhibited by NSAIDs like aspirin and ibuprofen?
COX-1
COX-2
Which anti-inflammatory drug binds to its receptor irreversibly?
Aspirin
What drug is a lipoxygenase inhibitor?
Zileuton
What drug is a selective COX-2 inhibitor?
Celecoxib
What drug is an analog of PGE2?
Misoprostol
What drugs are leukotriene-receptor antagonists?
Montelukast
Zafirlukast
Histamine has the following?
Powerful effects in smooth and cardiac muscles
Found on endothelial cells and nerves
More effect on guinea pigs than humans
Gastric acid secretion
Which traditional histamine blocker has sedative effects?
Diphenhydramine
Serotonin is found in?
Enterochromaffin cells(90% of the body)
Platelets which are able to concentrate the amine by means of active SERT
Nerve endings
5-HTin brain serotonergic neurons are involved in?
Mood, depression and anxiety
Sleep, apetite and vomitting
Pain, temperature regulation and migraine
What drug is a selective serotonin?
Buspirone; 5-HT1 agonist widely used as anxiolitic.
Angiotensis II and III effects are reversed by?
Renin inhibitors of synthesis or release
Angiotensis converting enzyme inhibitors
Kininase II inhibitors
Angiotensin receptor antagonist
The potency of ACE inhibitors like captopril can be explained by a dual action of?
Inhibition of synthesis of a powerful vasoconstrictor
Inhibition of destruction of a powerful vasodilatior
Prostaglandin synthesis is blocked in what pathway?
Cyclooxygenase pathway; It is the site of action of aspirin and NSAIDs
What vasoactive compound is known as the most potent vasoconstrictor?
Angiotensin II
What drug is an example of a non-selective 5-HT receptor agonist?
Ergotamin
