Autocoids

Question 1

What drug is an H2 antagonist?

Answer 1

Cimetidine

Ranitidine

Question 2

True or false, H4 is found on the bone marrow and white blood cells?

Answer 2

True

Question 3

True or false, tissue damage cannot activate kallikrein-kininogen-kinin system?

Answer 3

False

Question 4

What are the function of 5-HT?

Answer 4

Central chemical transmitter for tryptaminergic neurons of the brain

Regulation of GI motility and presitalsis

Precursor of melatonin

Question 5

True or false, 5-HT4 agonist-cisapride-anxiety or depression?

Answer 5

False; Cisapride is for GI motility and peristalsis

Question 6

Gastrointestinal bleeding from aspirin is considered a?

Answer 6

Side effect

Question 7

What are the autocoids involved in inflammatory reaction?

Answer 7

Histamine

Bradykinin

Serotonin

Prostanoids

Question 8

What are the physiologic effects mediated by histamine?

Answer 8

Vasodilation

Increased vascular permeability

Stimuation of sensory nerve endings

Question 9

Traditional H1 blockers have the following effects?

Answer 9

Promote sedation

Relieve allergic manifestations on the skin and mucous membrane

Emesis

Question 10

What drug is least sedating: loratadine, chlorpenamine, diphenhydramine and clemastine?

Answer 10

Loratadine; It does not cross the blood brain barrier.

Question 11

What are the therapeutic uses of H1 blockers?

Answer 11

Aid in sleeping

Countering motion sickness

Relieve itching and rashes in allergic disease

Question 12

What body functions involve 5-HT?

Answer 12

Fertility

Feeding

Sleeping

Mentation

Question 13

What enzyme class is responsible for converting tryptophan to serotonin?

Answer 13

Hydroxylase

Decarboxylase

Question 14

Prostanoids have the following clinical significance?

Answer 14

Platelet function

Inflammatory reaction

Reproduction

Question 15

What enzymes are inhibited by NSAIDs like aspirin and ibuprofen?

Answer 15

COX-1

COX-2

Question 16

Which anti-inflammatory drug binds to its receptor irreversibly?

Answer 16

Aspirin

Question 17

What drug is a lipoxygenase inhibitor?

Answer 17

Zileuton

Question 18

What drug is a selective COX-2 inhibitor?

Answer 18

Celecoxib

Question 19

What drug is an analog of PGE₂?

Answer 19

Misoprostol

Question 20

What drugs are leukotriene-receptor antagonists?

Answer 20

Montelukast

Zafirlukast

Question 21

Histamine has the following?

Answer 21

Powerful effects in smooth and cardiac muscles

Found on endothelial cells and nerves

More effect on guinea pigs than humans

Gastric acid secretion

Question 22

Which traditional histamine blocker has sedative effects?

Answer 22

Diphenhydramine

Question 23

Serotonin is found in?

Answer 23

Enterochromaffin cells(90% of the body)

Platelets which are able to concentrate the amine by means of active SERT

Nerve endings

Question 24

5-HTin brain serotonergic neurons are involved in?

Answer 24

Mood, depression and anxiety

Sleep, apetite and vomitting

Pain, temperature regulation and migraine

Question 25

What drug is a selective serotonin?

Answer 25

Buspirone; 5-HT1 agonist widely used as anxiolitic.

Question 26

Angiotensis II and III effects are reversed by?

Answer 26

Renin inhibitors of synthesis or release

Angiotensis converting enzyme inhibitors

Kininase II inhibitors

Angiotensin receptor antagonist

Question 27

The potency of ACE inhibitors like captopril can be explained by a dual action of?

Answer 27

Inhibition of synthesis of a powerful vasoconstrictor

Inhibition of destruction of a powerful vasodilatior

Question 28

Prostaglandin synthesis is blocked in what pathway?

Answer 28

Cyclooxygenase pathway; It is the site of action of aspirin and NSAIDs

Question 29

What vasoactive compound is known as the most potent vasoconstrictor?

Answer 29

Angiotensin II

Question 30

What drug is an example of a non-selective 5-HT receptor agonist?

Answer 30

Ergotamin