Autoantibody associations

Question 1

Anti-AChR

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin

Answer 3

SLE, antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome = Calcinosis, Raynaud’s, Esophageal dysmotility, Sclerodactyly, Telangiectasias)

Question 5

Anti-desmosome

Answer 5

Pemphigus vulgaris

Question 6

Antihemidesmosome

Answer 6

Bullous pemphigoid

Question 7

Anti-dsDNA, anti-Smith

Answer 7

SLE

Question 8

Anti-glutamic acid decarboxylase

Answer 8

T1DM

Question 9

Anti-histone

Answer 9

Drug-induced SLE

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Antimicrosomal

Answer 11

Hashimoto thyroiditis

Also antithyroglobulin

Question 12

Antimitochondrial

Answer 12

Primary biliary cirrhosis

Question 13

Antinuclear

Answer 13

Nonspecific

SLE

Question 14

Antiparietal cell

Answer 14

Pernicious anemia

Question 15

Anti-Scl-70

Answer 15

AKA anti-DNA topoisomerase I

Diffuse scleroderma

Question 16

Anti-smooth muscle

Answer 16

Autoimmune hepatitis

Question 17

Anti-SSA, Anti-SSB

Answer 17

Sjogren syndrome

Question 18

Anti-TSH receptor

Answer 18

Graves disease

Question 19

Anti-U1 RNP

Answer 19

Mixed Connective Tissue Disease

Question 20

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac disease

Question 21

p-ANCA

Answer 21

AKA MPO-ANCA

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Question 22

c-ANCA

Answer 22

AKA PR3-ANCA

Granulomatosis with polyangiitis (Wegener’s)

Question 23

IgM targetting IgG Fc region

Answer 23

AKA RF
RA
RF is not as specific as anti-CCP