Autoantibodies and Rheumatic Markers Flashcards
Anti-histone
Drug induced lupus
ANA
SLE (95%)Drug induced lupus (100%)Mixed connective tissue disease (95%)Sjogren’s (70%)Scleroderma/CREST (80%)Dermatomyositis/polymyositis (80%)RA (50%)
Anti-ds DNA
SLE (60%)Sjogren’s (30%)
Anti-Sm
SLE (40%)
Anti-Ro/La (SS-A/SS-B)
SLE (40%) and neonatal lupusSjogren’s (50%)
Anti-leucine aminopeptidase
Sjogren’s (60%)SLE (15%)
Anti-scl-70 (antitopoisomerase I)
Scleroderma (20%)CREST (10%)
Anti-centromere
Scleroderma (30%)CREST (80%)
RF
RA (70%)
C-ANCA
Wegener’s granulomatosis
P-ANCA
Polyarteritis nodosaChurg-Strauss Syndrome
Lupus anticoagulant
Antiphospholipid antibody syndrome
Anti-uroporphyrin isomerase ribonucleoprotein (anti-U1-RNP)
Mixed connective tissue disease (90%)SLE (40%)Scleroderma (15%)Dermatomyositis/polymyositis (15%)CREST (10%)
Anti-Jo-1 (antisynthetase)
Dermatomyositis/polymyositis
Anti-signal recognition particle
Dermatomyositis/polymyositis