Autoantibodies Flashcards
1
Q
Ab in RA
A
- anti-CCP (more sensitive) (anticyclic citrullinated peptide antibodies)
- RF (rheumatoid factor)
2
Q
Ab in Granulomatosis with polyangiitis (Wegener’s)
A
c-ANCA (and p-ANCA)
3
Q
c-ANCA
A
granulomatosis with polyangiitis (Wegener’s)
4
Q
Ab in Eosinophilic granulomatosis with polyangiitis (EGPA)/Churg-Strauss syndrome
A
p-ANCA
5
Q
p-ANCA
A
- Eosinophilic granulomatosis with polyangiitis (EGPA)/Churg-Strauss syndrome
- microscopic polyangitis
- (Wegener’s/GPA)
6
Q
Ab in SLE
A
- ANA (sensitive)
- anti-dsDNA (specific)
- anti-Smith (specific)
- (antiphospholipid)
7
Q
Ab in Antiphospholipid syndrome
A
Antiphospholipid Abs:
- anti-cardiolipin Ab (aCL)
- lupus anticoagulant (LAC)
8
Q
What is Anti-Smith most specific to?
A
SLE
9
Q
What is Anti-centromere most associated with?
A
Limited cutaneous systemic sclerosis (CREST)
10
Q
What are Anti-Ro and Anti-La most associated with?
A
Sjogren’s syndrome
11
Q
What is Anti-Scl-70 most associated with?
A
Systemic sclerosis
12
Q
What is Anti-Jo-1 most associated with?
A
Dermatomyositis
13
Q
Ab in systemic sclerosis
A
- ANA (90%)
- RF (30%)
- anti-centromere in limited
- anti-Scl-70 in diffuse
- anti-RNA polymerase I and III in diffuse
14
Q
Ab in Graves disease
A
anti-TSH receptor Ab (TRAb)
15
Q
Ab in Hashimoto’s
A
- antithyroid peroxidase (anti-TPO)
- antithyroglobulin
