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Immunology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-glomerular basement membrane

A

goodpasture syndrome

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3
Q

Anti-Beta2 glycoprotein

A

antiphospholipid syndrome

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4
Q

anti-cardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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5
Q

anticentromere

A

Limited scleroderma (CREST syndrome)

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6
Q

Anti-desmoglein (anti-desmosome)

A

pemphigus vulgaris

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7
Q

Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

A

Type I diabetes mellitus

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8
Q

anti-hemidesmosome

A

bullous pemphigoid

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9
Q

Anti-synthetase (anti-Jo-1), anti SRP, anti helicase (anti Mi-2)

A

polymyositis, dermatomyositis

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10
Q

Anti-microsomal, anti-thyroglobulin, anti- thyroid peroxidase,

A

hashimoto thyroiditis

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11
Q

anti-mitochondrial

A

primary biliary cirrhosis

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12
Q

anti-parietal cell, anti-intrinsic factor

A

pernicious anemia

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13
Q

anti-phospholipase A2 receptor

A

primary membranous nephropathy

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14
Q

anti-Scl-50 (anti-DNA topoisomerase I)

A

scleroderma (diffuse)

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15
Q

Anti-smooth muscle

A

autoimmune hepatitis type 1

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16
Q

anti-SSa, anti-SSb (anti-Ro & anti-La)

A

Sjogren syndrome

17
Q

Anti-TSH receptor

A

Graves disease

18
Q

Anti-presynaptic voltage gated calcium channel

A

Lambert Eaton myasthenic syndrome

19
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac disease

20
Q

MPO-ANCA/p-ANCA

A

microscopic polyangiitis eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome), ulcerative colitis

21
Q

PR3-ANCA/c-ANCA

A

Granulomatosis with Polyangiitis (Wegner)

22
Q

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (cyclic citrullinated peptide)

A

Rheumatoid Arthritis

23
Q

ANA (ANA)

A

Nonspecific screening antibody, often associated with SLE

24
Q

Anti-dsDNA, Anti Smith (snRNPs, part of spliceosome)

A

SLE

25
Q

Anti- histone

A

Drug induced lupus

26
Q

Anti-U1 RNP (ribonucleoprotein, nRNP part of spliceosome )

A

Mixed connective tissue disease

Immunology (2 decks)

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