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Immunology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Adrenal failure -Autoimmune

A

Adrenal cortex

Sensitivity 60-90%

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2
Q

Coeliac disease

A

GET

Gliadin

Endomysium (IgA)
Sensitivity 70-90%
Specificity High

TTG (IgA) anti-transglutaminase antibodies
Sensitivity 70-90%
Specificity High

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3
Q

Dressler’s syndrome

A

Cardiac muscle

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4
Q

Goodpasture’s syndrome

A

Glomerular BM
Sensitivity High
Specificity High

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5
Q

Grave’s disease (pregnant)

A

TSH receptor

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6
Q

Haemolytic anaemia-Autoimmune

A

Rhesus antigen

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7
Q

Hepatitis-Autoimmune

A

Smooth muscle
Sensitivity 70%
Specificity Low

LKM (liver kidney microsomal antibodies)
Sensitivity Low
Specificity High

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8
Q

Insulin dependent diabetes mellitus

A

Islet cells (early)
Sensitivity 90%
Specificity High

GAD (glutamic acid decarboxylase)
Sensitivity Varies
Specificity High

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9
Q

Microscopic polyangiitis (MPA)

A

pANCA
Sensitivity 50%
Specificity Low

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10
Q

Myasthenia gravis

A

Acetylcholine receptor
Sensitivity 80-90%
Specificity High

MUSK

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11
Q

Ovarian failure-Autoimmune

A

Ovary

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12
Q

Parathyroid failure-Autoimmune

A

Parathyroid

Sensitivity 10%

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13
Q

Pemphigoid

A

Skin BM

Sensitivity 90%

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14
Q

Pemphigus

A

Desmosomes
Sensitivity 70%

Desmoglein 3

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15
Q

Peripheral neuropathy

A

Ganglioside (GM1)

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16
Q

Pernicious anaemia

A

Parietal cell
Sensitivity 90%
Specificity Low

Intrinsic factor
Sensitivity 66%
Specificity High

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17
Q

Polymyositis/Dermatomyositis

A

ANA (Antinuclear Antibodies )
Sensitivity 40-70%
Specificity Low

Jo-1
Sensitivity 20%
Specificity High

Jo 1 (histidyl tRNA synthetase) is a member of the amino acyl-tRNA synthetase family of enzymes found in all nucleated cells.

18
Q

Primary biliary cirrhosis

A

Mitochondria
Sensitivity 100%
Specificity High

19
Q

Rheumatoid arthritis

A

Rheumatoid factor
Sensitivity 70%
Specificity Low

Anti-cyclic citrullinated peptide (anti-CCP)

20
Q

Sjogren’s syndrome

A

ANA
Sensitivity 40-70%
Specificity Low

Ro and La
Sensitivity 40-70%
Specificity Low

21
Q

Systemic lupus erythematosus

A

ANA
Sensitivity >99%
Specificity Low

dsDNA
Sensitivity 70-90%
Specificity High

Sm
Sensitivity 30%
Specificity High

22
Q

Systemic sclerosis-diffuse

A

ANA
Sensitivity 60-90%
Specificity Low

Scl-70
Sensitivity 20%
Specificity High

23
Q

Systemic sclerosis-limited

A

ANA
Sensitivity 60-90%
Specificity Low

Centromere

24
Q

Thrombocytopenia-Autoimmune

A

GpIIb/IIIa

25
Q

Thrombosis/ miscarriage

A

Phospholipid
Specificity low

Cardiolipid

26
Q

Thyroiditis- Autoimmune/Hashimoto’s

A

Thyroid peroxidase
Sensitivity High
Specificity Low

Antimicrosomal
antithyroglobulin
anti-thyroid pyroxidase

27
Q

Granulomatosis with polyangiitis

GPA, Wegener’s Granulomatosis

A

cANCA (Cytoplasmic antineutrophil cytoplasmic antibodies)
Sensitivity High
Specificity Moderate

28
Q

Specificity

A

Measures the proportion of negatives that are correctly identified as such

= True negatives/ All test negatives

29
Q

Sensitivity

A

The proportion of true positives picked up by the test

= True positives/ All test positives

30
Q

MHC II DR2 only

A

Goodpasture syndrome
Hayfever
MS

31
Q

MHC II DR3 only

32
Q

MHC II DR2 DR3

33
Q

MHC II DR3 DR4

34
Q

MHC II DR3 DR5

A

Hashimoto thyroiditis

35
Q

MHC II DR4 only

A

Rheumatoid arthritis

36
Q

MHC I A3 only

A

Hemochromatosis

37
Q

MHC II DQ2/DQ8

A

Celiac disease

38
Q

Anti-beta2 glycoprotein

A

Antiphospholipid syndrome

39
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A

Polymyosiitis, dermatomyosiitis

40
Q

B27

A

Reactive arthritis
IBD arthritis
Psoriatic arthritis
Ankylosing spondylitis

41
Q

MHC II DR5 only

A

Pernicious anaemia

Immunology (3 decks)

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