Autoantibodies Flashcards

1
Q

Anti-centromere Ab

A

Limited Scleroderma (CREST)

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2
Q

Anti-desmoglein (desmosome) Ab

A

Pemphigus Vulgaris

Type II HS

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3
Q

Anti-dsDNA, Anti-Smith

A

SLE

Type III HS

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4
Q

ANti-glutamic acid decarboxylase (GAD-65) Ab

A

Type I DM

Type IV HS

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5
Q

Anti-hemidesmosome

A

Bulbous Pemphigoid

Type II HS

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6
Q

Anti-histone Ab

A

Drug-induced SLE (Procainamide, Hydralazine, Isoniazid)

Type III HS

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7
Q

Anti-Jo-1, Anti-SRP, Anti-Mi-2

A

Polymyositis, dermatomyositis

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8
Q

Antimicrobials, Antithyroglobulin

A

Hashimoto Thydoiditis

Type IV HS

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9
Q

Antimitochondrial

A

Primary biliary cirrhosis (cholangitis)

Type IV HS

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10
Q

Antinuclear Ab (ANA)

A

SLE (nonspecific)

Type III HS

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11
Q

Antiparietal cell

A

Pernicious Anemia

Type IV HS

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12
Q

Antiphospholipase A2 receptor

A

Primary membranous nephropathy

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13
Q

Anti-Scl-70 Ab (Anti-DNA topoisomerase I)

A

Diffuse Scleroderma

Type II HS

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14
Q

ANti-smooth muscle, Anti-LKM (liver, kidney, microsomal), Antinuclear Ab (ANA)

A

Autoimmune Hepatitis Type I

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15
Q

Anti-SSA (Anti-Ro), Anti-SSB (Anti-La)

A

Sjogren Syndrome

Type II HS

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16
Q

Anti-TSH receptor

A

Graves Disease

Type II HS

17
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

18
Q

Voltage-gated Ca2+ channel Ab

A

Lambert-Eaton Syndrome

Type II HS

19
Q

Anti-endomysial IgA, Anti-tissue glutaminase IgA

A

Celiac Disease

Type IV HS

20
Q

MPO-ANCA (p-ANCA)

A

Microscopic Polyangiitis, Eosinophilic Granulomatosis w/ Polyangiitis (Churg-Strauss)

21
Q

PR3-ANCA (c-ANCA)

A

Granulomatosis w/ Polyangiitis (Wegener)

22
Q

Rheumatoid factor (IgM targets Fc of IgG), Anti-CCP

A
Rheumatoid Arthritis (Anti-CCP more specific)
Type IV HS
23
Q

Anti-ACh receptor Ab

A

Myasthenia Gravis

Type II HS

24
Q

Anti-basement membrane Ab

A

Goodpasture Syndrome

Type II HS

25
Q

Anticardiolipin

A

SLE, Antiphospholipid Syndrome