Autoantibodies

Question 1

Goodpasture

Answer 1

Anti-BM

Question 2

SLE, antiphospholipid syndrome

Answer 2

Anticardiolipin

Question 3

Limited Scleroderma (CREST syndrome)

Answer 3

Anticentromere

Question 4

Pemphigus vulgaris

Answer 4

Anti-desmosome (separate keratinocytes from basal layer of epidermis – easily exfoliate)

Question 5

SLE

Answer 5

Anticardiolipin, Anti-dsDNA, anti-Smith, Antinuclear antibodies (nonspecific)

Question 6

T1DM

Answer 6

Anti-glutamic acid decarboxylase (GAD-65)

Question 7

Bullous pemphigoid

Answer 7

Antihemidesmosome (between epidermis and dermis)

Question 8

Drug-induced lupus

Answer 8

anti-histone

Question 9

Polymyositis, dermatomyositis

Answer 9

anti-Jo-1, anti-SRP, anti-Mi-2

Question 10

Hashimoto thyroiditis

Answer 10

Antimicrosomal, antithyroglobulin

Question 11

Primary biliary cirrhosis

Answer 11

Antimitochondria

Question 12

Pernicious anemia

Answer 12

Antiparietal cell

Question 13

Diffuse scleroderma

Answer 13

Anti-Scl-70 (anti-DNA topoisomerase I)

Question 14

Autoimmune hepatitis

Answer 14

anti-smooth muscle

Question 15

Sjogren’s syndrome

Answer 15

Anti-SSA, Anti-SSB (anti-Ro, anti-La)

destroy salivary and lacrimal glands –> dry mouth and eyes

Question 16

Graves disease

Answer 16

anti-TSH receptor

Question 17

Mixed CT disease

Answer 17

Anti-U1 RNP (ribonucleoprotein)

Question 18

Celiac disease

Answer 18

IgA anti-endomysial, IgA anti-tissue transglutaminase

Question 19

Microscopic polyangiitis and Churg Strauss

Answer 19

MPO-ANCA/p-ANCA

Question 20

Granulomatosis with polyangiitis (Wegener)

Answer 20

PR3-ANCA/c-ANCA

Question 21

RA

Answer 21

Rheumatoid factor (IgM that targets IgG Fc region) and anti-CCP

Question 22

Myasthenia gravis

Answer 22

Anti-ACh receptor