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autoantibodies Flashcards

1
Q

ANA target

A

antinuclear antibodies - bind to contents of cell’s nucleus

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2
Q

anti - La disease

A

sjogren syndrome

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3
Q

rheumatoid factor target

A

most commonly IgM

specific to IgG Fc region

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4
Q

anti - SCL - 70 target

A

anti - DNA topoisomerase I

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5
Q

anti - tTG disease

A

celiac disease

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6
Q

pANCA disease

A

microscopic polyangitis

churg-strauss syndrome

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7
Q

anti - TSH receptor target

A

thyroid receptor

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8
Q

anti - Ro target

A

anti - SSA - ribonucleoproteins

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9
Q

anti - dsDNA disease

A

SLE

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10
Q

anti - actin target

A

actin

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11
Q

cANCA target

A

proteins in neutrophil cytoplasm

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12
Q

anti - CCP disease

A

rheumatoid arthritis

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13
Q

anti - centromere target

A

centromere

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14
Q

anti - La target

A

anti - SSB - ribonucleoproteins

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15
Q

anti - actin disease

A

celiac disease (# of antibodies correlated w/level of intestinal damage)

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16
Q

ANA disease

A

SLE

non-spec for autoimmune diseases

17
Q

anti - thyroid peroxidase disease

A

grave’s, hashimoto, nodular goiter, thyroid carcinoma

18
Q

anti - nicotinic acetylcholine receptor target

A

nicotinic acetylcholine receptor

19
Q

cANCA disease

A

wegener’s (granulomatosis w/polyangitis)

20
Q

anti - CCP target

A

cyclic citrullinated peptide

21
Q

rheumatoid factor disease

A

rheumatoid arthritis

22
Q

anti - SCL - 70 disease

A

diffuse scleroderma

systemic sclerosis

23
Q

anti - dsDNA target

24
Q

pANCA target

A

neutrophil perinuclear

25
Q

anti - thyroid peroxidase target

A

autoantigen TPO - catalyses iodine oxidation and iodination reactions

26
Q

anti - tTG target

A

IgA anti - tissue transglutaminase

27
Q

anti - centromere disease

28
Q

anti - nicotinic acetylcholine receptor disease

A

myasthenia gravis

29
Q

anti - TSH receptor disease

A

grave’s disease

micro (8 decks)

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