Autoantibodies

Question 1

Antinuclear Antibody (ANA) Test

Answer 1

A sensitive but non-specific for Autoimmune diseases. May be ordered as an initial test. Positive for:

• Lupus
• Sjogren syndrome
• RA
• Autoimmune hepatitis

Question 2

Anti-dsDNA

Answer 2

Specific test for LUPUS

Question 3

ANCA Antibodies

Answer 3

Sensitive for:
- Systemic vasculitis

Can also help differentiate between Crohns and UC (positive means more likely to be UC than Crohn’s)

Question 4

Anticentromere Antibody (ACA)

Answer 4

Sensitive for:
- Scleroderma

Ordered when there are symptoms suggestive of CREST syndrome

Question 5

Histone antibodies

Answer 5

Used to diagnose Drug-induced lupus

Question 6

Anti-CCP antibodies

Answer 6

Used to diagnose:

• Rheumatoid Arthritis
• Can also be used to estimate disease severity*

Question 7

Anti-RNP antibodies

Answer 7

Mixed connective tissue disease

Question 8

Anti-Sm Antibodies

Answer 8

Highly specific test for LUPUS

Question 9

Anti-Ro

Answer 9

Most often used to diagnose SJOGREN Syndrome

Question 10

Anti-La

Answer 10

Tested with Anti-Ro to test for SJOGREN Syndrome

Question 11

Anti-Jo

Answer 11

Used to test for POLYMYOSITIS

Question 12

Antiphospholipid Antibodies (APA)

Answer 12

Antiphospholipid Syndrome

Question 13

Anti-Tissue Transglutaminase (anti-tTG)/ Anti-Gliadin Antibodies (AGA)

Answer 13

Coeliac’s disease

Question 14

Anti-TPO antibodies

Answer 14

Autoimmune thyroid tests

Question 15

Anti-smooth muscle antibodies (SMA)

Answer 15

Autoimmune hepatitis

Question 16

Antimitochondrial Antibodies (AMA)

Answer 16

Primary Biliary Cholangitis/ Primary Biliary Cirrhosis (PBC)

Question 17

Liver Kidney Microsome Type 1 antibodies (anti-LKM-1)

Answer 17

Autoimmune hepatitis

Question 18

Acetylcholine Receptor Antibody (AChR)

Answer 18

Myasthenia Gravis (MG)