(Auto)antibodies in infection and inflammation

Question 1

Give 3x cell type recruited as effector cell by monoclonal antibody therapy

Answer 1

neutrophils (cetuximab = IgG, cancer)

Question 2

Name the 3 main functions of antibodies in preventing infection. Explain your answer and include structure of different parts of the antibody in your answer.

Answer 2

Neutralization:
preventing pathogens from entering or damaging cells by binding to them

Opsonization:
stimulating removal of pathogens by macrophages and other cells by coating the pathogen

Complement activation

and triggering destruction of pathogens by stimulating other immune responses such as the complement pathway