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Quick Pathology > Auto-antibodies > Flashcards

Auto-antibodies Flashcards

1
Q

Cardiolipin

A

Anti-phospholipid syndrome

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2
Q

Apolipoprotein H / anti-β2 glycoprotein

A

Anti-phospholipid syndrome

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3
Q

Smooth muscle

A

Autoimmune hepatitis

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4
Q

Liver Kidney Microsomal

A

Autoimmune hepatitis

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5
Q

Soluble Liver Antigen

A

Autoimmune hepatitis

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6
Q

Actin

A

Autoimmune hepatitis

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7
Q

Rhesus

A

AIHA

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8
Q

pANCA / MPO (Perinuclear)

A

Churg Strauss

Microscopic polyangiitis

Primary sclerosing cholangitis

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9
Q

cANCA / proteinase-3 (Cytoplasmic)

A

Wegner’s

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10
Q

Platelet (GPIIb/IIIa)

A

ITP

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11
Q

dsDNA (Homogenous)

A

SLE

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12
Q

Ro (Speckled)

A

SLE

Sjogren’s

Congenital Heart Block

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13
Q

La (Speckled)

A

SLE

Sjogren’s

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14
Q

Sm (Speckled)

A

SLE

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15
Q

U1RNP (Speckled)

A

SLE

MCTD

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16
Q

Endomysial (IgA)

A

Coeliac

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17
Q

Tissue Trans Glutaminase (IgA)

A

Coeliac

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18
Q

Gliadin (IgG / IgA)

A

Coeliac

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19
Q

Jo-1 (t-RNA synthetase) (Cytoplasmic speckled)

A

Dermatomyositis

Polymyositis

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20
Q

SCL-70 (Topoisomerase) (Nucleolar)

A

Diffuse Systemic sclerosis

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21
Q

RNA Pol 1,2,3 (Nucleolar)

A

Diffuse Systemic sclerosis

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22
Q

Centromere

A

CREST

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23
Q

Fibrillarin (Nucleolar)

A

Diffuse Systemic sclerosis

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24
Q

GBM (NC α3 collagen IV)

A

Goodpastures

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25
Q

TSH

A

Graves

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26
Q

Tg

A

Hashimoto’s

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27
Q

TPO

A

Hashimoto’s

Graves (50%)

28
Q

ACh

A

Myasthenia

29
Q

Voltage gated Ca channels

A

Lambert-Eaton

30
Q

Parietal cells

A

Pernicious anaemia / AI gastritis

31
Q

Intrinsic factor

A

Pernicious anaemia / AI gastritis

32
Q

Mitochondrial (cytoplasmic)

A

Primary biliary cirrhosis

33
Q

CCP

A

Rheumatoid arthritis

34
Q

GAD

A

DM

35
Q

Desmosomes (cadherins)

A

Pemphigus

36
Q

Hemidesomosomes (collagen XVII)

A

Pemphigoid

37
Q

Histone

A

Drug-induced lupus

38
Q

AIHA

A

Rhesus

39
Q

Anti-phospholipid syndrome

A

Cardiolipin

Apolipoprotein H / anti-β2 glycoprotein

40
Q

Autoimmune hepatitis

A

Smooth muscle

Liver Kidney Microsomal

Soluble Liver Antigen

Actin

41
Q

Churg Strauss

A

pANCA / MPO (Perinuclear)

42
Q

Coeliac

A

Endomysial (IgA)
Tissue Trans Glutaminase (IgA)
Gliadin (IgG / IgA)

43
Q

Congenital heart block

A

Ro (Speckled)

44
Q

CREST

A

Centromere

45
Q

Dermatomyositis

A

Jo-1 (t-RNA synthetase) (Cytoplasmic speckled)

46
Q

Diffuse Systemic sclerosis

A

SCL-70 (Topoisomerase)
(Nucleolar)

RNA Pol 1,2,3
(Nucleolar)

Fibrillarin (Nucleolar)

47
Q

DM

A

GAD

48
Q

Drug-induced lupus

A

Histone

49
Q

Goodpastures

A

GBM (NC α3 collagen IV)

50
Q

Graves

A

TSH

TPO (50%)

51
Q

Hashimoto’s

A

TPO

Tg

52
Q

ITP

A

Platelet (GPIIb/IIIa)

53
Q

Lambert-Eaton

A

Voltage gated Ca channels

54
Q

MCTD

A

U1RNP (Speckled)

55
Q

Microscopic polyangitis

A

pANCA / MPO (Perinuclear)

56
Q

Myasthenia

A

ACh

57
Q

Pemphigoid

A

Hemidesomosomes (collagen XVII)

58
Q

Pemphigus

A

Desmosomes (cadherins)

59
Q

Pernicious anaemia / AI gastritis

A

Parietal cells

Intrinsic factor

60
Q

Polymyositis

A

Jo-1 (t-RNA synthetase) (Cytoplasmic speckled)

61
Q

Primary biliary cirrhosis

A

Mitochondrial (cytoplasmic)

Ant-smooth muscle

62
Q

AI hepatitis

A

Anti-smooth muscle

63
Q

Primary sclerosing cholangitis

A

pANCA / MPO (Perinuclear)

64
Q

Rheumatoid arthritis

A

CCP

Rheumatoid factor (IgM against the Fc portion of IgG)

65
Q

Sjogren’s

A

Ro (Speckled)

La (Speckled)

66
Q

SLE

A

dsDNA (Homogenous)

Ro (Speckled)

La (Speckled)

Sm (Speckled)

U1RNP (Speckled)

67
Q

Wegner’s

A

cANCA / proteinase-3 (Cytoplasmic)

Quick Pathology (7 decks)

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