Auto-Antibodies

Question 1

ANCA - PR3

Answer 1

80-90% of Granulomatosis with polyangiitis (GPA)

Question 2

ANCA - MPO

Answer 2

50% of Microscopic polyangiitis (MPA)

Question 3

Anti AcH-Receptor

Answer 3

Myasthenia gravis (MG), specificity ~ 100%
- IF NEGATIVE Anti-MuSK SBx (5% of MG)

Question 4

Anti-Voltage-gated calcium channel (VGCC)

Answer 4

Paraneoplastic - Lambert-Eaton syndrome (SCLC)

Question 5

Anti-Sox1

Answer 5

Paraneoplastic - Lambert-Eaton syndrome (SCLC)

Question 6

Anti-Aquaporin 4 (AQP-4)

Answer 6

Neuromyelitis optica spectrum disorders (NMOSD)

Question 7

Anti-GM1

Answer 7

Multifocal motor neuropathy with conduction block (MMN)

Guillain-Barre syndrome

Question 8

Anti-GD3

Answer 8

Acute motor axonal neuropathy (AMAN)

Question 9

Anti-GQ1b

Answer 9

Miller-Fisher syndrome - Ataxia, areflexia and opthalmoplegia

Question 10

Anti-GQ1b

Answer 10

Miller-Fisher syndrome - Ataxia, areflexia and opthalmoplegia

Question 11

Anti-voltage-gated potassium channel (VGKC)

Answer 11

Autoimmune limbic encephalitis

- Morvan’s syndrome - neuromyotonia (NMT), pain, hyperhydrosis, weight loss, severe insomnia and hallucinations

Question 12

Anti-AMA

Answer 12

Autoimmune hepatitis Type 1 > 2

Question 13

Anti-SM

Answer 13

Autoimmune hepatitis Type 1 > 2

Question 14

Anti-LKM-1

Answer 14

Autoimmune Hepatitis Type 2

Question 15

Anti-Jo1

Answer 15

Anti-Synthetase syndrome

- Mechanic hands, myopathy, lung fibrosis

Question 16

Anti-SRP

Answer 16

Necrotising myopathy

Question 17

Anti-HMGCR

Answer 17

Necrotising myopathy

Question 18

Anti-MDA5

Answer 18

Amyopathic DM
ILD
Poor prognosis

Question 19

Anti-TIF1-gamma

Answer 19

Dermatomyositis

- Cancer related

Question 20

Anti-Ro /Anti-La

Answer 20

Primary Sjogrens, RA

Neonatal heart block

Question 20

Anti-Ro /Anti-La

Answer 20

Primary Sjogrens, RA

Neonatal heart block

Question 21

Anti-centromere

Answer 21

Limited Scleroderma

- Higher risk of primary PAH

Question 22

Anti-Scl-70 (Anti-topoisomerase I)

Answer 22

Diffuse scleroderma

- Higher risk of severe ILD (which leads to secondary PAH)

Question 23

Anti-RNA polymerase III

Answer 23

Scleroderma

- Higher risk of renal crisis

Question 24

Anti-phospholipid antibodies - risk of thrombosis order

Answer 24

LA>B2GP1>aCL for risk of thrombosis

Question 25

Anti-cN1A

Answer 25

Inclusion Body Myositis

Question 26

Anti-CCP

Answer 26

RA

Question 27

Anti-dsDNA

Answer 27

SLE

- Specific, most common

Question 28

Anti-Sm (Smith)

Answer 28

SLE

- MOST Specific, only 5% of cases though

Question 29

Anti-U1RNP

Answer 29

MCTD

Question 30

Anti-U1RNP

Answer 30

MCTD

Question 31

Anti-PLA2R

Answer 31

Primary membranous GN

Question 32

Anti-histone

Answer 32

Drug Induced Lupus

Question 33

Anti-NMDAR

Answer 33

Anti-NMDA receptor autoimmune encephalitis

Question 34

Anti-desmoglein (anti-desmosome)

Answer 34

Pemphigus vulgaris

Question 35

Anti-hemidesmosome

Answer 35

Bullous pemphigoid

Question 36

Anti-GBM

Answer 36

Goodpasture’s Disease

Question 37

Anti-parietal cell

Anti-intrinsic factor

Answer 37

Pernicious Anaemia