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RACP Written Exam > Auto-Antibodies > Flashcards

Auto-Antibodies Flashcards

1
Q

ANCA - PR3

A

80-90% of Granulomatosis with polyangiitis (GPA)

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2
Q

ANCA - MPO

A

50% of Microscopic polyangiitis (MPA)

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3
Q

Anti AcH-Receptor

A 
Myasthenia gravis (MG), specificity ~ 100%
- IF NEGATIVE Anti-MuSK SBx (5% of MG)
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4
Q

Anti-Voltage-gated calcium channel (VGCC)

A

Paraneoplastic - Lambert-Eaton syndrome (SCLC)

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5
Q

Anti-Sox1

A

Paraneoplastic - Lambert-Eaton syndrome (SCLC)

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6
Q

Anti-Aquaporin 4 (AQP-4)

A

Neuromyelitis optica spectrum disorders (NMOSD)

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7
Q

Anti-GM1

A

Multifocal motor neuropathy with conduction block (MMN)

Guillain-Barre syndrome

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8
Q

Anti-GD3

A

Acute motor axonal neuropathy (AMAN)

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9
Q

Anti-GQ1b

A

Miller-Fisher syndrome - Ataxia, areflexia and opthalmoplegia

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10
Q

Anti-GQ1b

A

Miller-Fisher syndrome - Ataxia, areflexia and opthalmoplegia

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11
Q

Anti-voltage-gated potassium channel (VGKC)

A

Autoimmune limbic encephalitis

- Morvan’s syndrome - neuromyotonia (NMT), pain, hyperhydrosis, weight loss, severe insomnia and hallucinations

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12
Q

Anti-AMA

A

Autoimmune hepatitis Type 1 > 2

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13
Q

Anti-SM

A

Autoimmune hepatitis Type 1 > 2

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14
Q

Anti-LKM-1

A

Autoimmune Hepatitis Type 2

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15
Q

Anti-Jo1

A

Anti-Synthetase syndrome

- Mechanic hands, myopathy, lung fibrosis

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16
Q

Anti-SRP

A

Necrotising myopathy

17
Q

Anti-HMGCR

A

Necrotising myopathy

18
Q

Anti-MDA5

A

Amyopathic DM
ILD
Poor prognosis

19
Q

Anti-TIF1-gamma

A

Dermatomyositis

- Cancer related

20
Q

Anti-Ro /Anti-La

A

Primary Sjogrens, RA

Neonatal heart block

20
Q

Anti-Ro /Anti-La

A

Primary Sjogrens, RA

Neonatal heart block

21
Q

Anti-centromere

A

Limited Scleroderma

- Higher risk of primary PAH

22
Q

Anti-Scl-70 (Anti-topoisomerase I)

A

Diffuse scleroderma

- Higher risk of severe ILD (which leads to secondary PAH)

23
Q

Anti-RNA polymerase III

A

Scleroderma

- Higher risk of renal crisis

24
Q

Anti-phospholipid antibodies - risk of thrombosis order

A

LA>B2GP1>aCL for risk of thrombosis

25
Q

Anti-cN1A

A

Inclusion Body Myositis

26
Q

Anti-CCP

A

RA

27
Q

Anti-dsDNA

A

SLE

- Specific, most common

28
Q

Anti-Sm (Smith)

A

SLE

- MOST Specific, only 5% of cases though

29
Q

Anti-U1RNP

A

MCTD

30
Q

Anti-U1RNP

A

MCTD

31
Q

Anti-PLA2R

A

Primary membranous GN

32
Q

Anti-histone

A

Drug Induced Lupus

33
Q

Anti-NMDAR

A

Anti-NMDA receptor autoimmune encephalitis

34
Q

Anti-desmoglein (anti-desmosome)

A

Pemphigus vulgaris

35
Q

Anti-hemidesmosome

A

Bullous pemphigoid

36
Q

Anti-GBM

A

Goodpasture’s Disease

37
Q

Anti-parietal cell

Anti-intrinsic factor

A

Pernicious Anaemia

RACP Written Exam (22 decks)

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