Autism Spectrum Disorder Flashcards

1
Q

What are the criteria for social deficits of autism?

A

All of:

  • deficits of social-emotional reciprocity
  • deficits in nonverbal communication
  • deficits in developing, maintaining, and understanding relationships
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2
Q

What are the criteria for repetitive behaviours of autism?

A

2 of:

1) stereotyped or repetitive motor movements
2) Insistence on sameness
3) Fixed interests
4) Hyper/hyporeactivity to sensory input

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3
Q

What are differential diagnoses of ASD?

A
  • Intellectual disability
  • language disorder
  • ADHD
  • Anxiety disorder
  • Selective mutism
  • Language disorders and social (pragmatic) communication disorder
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4
Q

What are screening assessments for autism?

A
  • GOOD CLINICAL JUDGMENT
  • Social Communication Questionnaire (SCQ)
  • Social Responsiveness Scale (SRS)
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5
Q

What are diagnostic assessment tools for ASD?

A
  • Autism diagnostic interview (ADI)

- Autism diagnostic observation scheduling (ADOS)

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6
Q

What investigations would you order if you suspect ASD?

A
  • Cognitive assessment
  • Speech language assessment
  • Physical exam
  • Genetic testing (clinical microarray)
  • Brain/EEG if indicated
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7
Q

What is the prevalence of ASD?

A

1.85%

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8
Q

What is the male:female ratio of ASD?

A

4:1

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9
Q

How many patients with ASD have intellectual disability?

A

33%

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10
Q

How many patients with ASD have seizure disorders?

A

20%

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11
Q

What is the IQ “cutoff” for intellectual disability?

A

IQ of 70

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12
Q

What are the neuroanatomical changes seen in ASD?

A

large head circumference, increased brain weight

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13
Q

How many ASD patients have abnormalities on microarray?

A

5-10%

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14
Q

What is the primary psychological theory of ASD?

A

Patients with ASD lack a “theory of mind” - the ability to understand or make inferences about other people’s thoughts

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15
Q

What is the treatment for ASD?

A
  • Applied behaviour analysis (ABA)

- Intensive behavioural intervention (IBI) - 20 h/week

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16
Q

What are the pharmacological treatments of ASD?

A
  • No pharmacological interventions for ASD itself
  • For aggression: risperidone, aripiprazole are FDA approved for use in children with ASD.
    Haloperidone, olanzapine, lurasidone also better than placebo.

For repetitive behaviours: risperidone for children; fluvoxemine and fluoxetine for adults

17
Q

What are the treatments for ASD and comorbid ADHD?

A
  • Guanfacine
  • Methylphenidate
  • Atomoxetine
18
Q

What is the prevalence of intellectual disability?

A

1%