Autacoids - Serotonin Flashcards
To check for 5-HT levels in the body, check for which metabolite?
5-hydroxyindoleacetic acid (primary urinary metabolite of serotonin)
5-HT2C agonist can be used for (hypertension/depression/chemotherapy) _______.
hypertension
(Lorcaserin/Dexfenfluramine/Both) ___ are 5-HT2C agonists which can be used for obesity as appetite suppressants.
Both
Triptans is a 5-HT(1D/1B/both) ___ agonist which can activate receptors on presynaptic trigeminal nerve endings, inhibiting release of vasodilating peptides and suppressing excessive firings of these nerve endings. This can prevent migraine attacks.
Both
5-HT1D/1B agonist (Sumatriptan) is contraindicated for patients at risk for (patients undergoing cardiac surgery/coronary artery disease/both) ____.
CAD
5-HT2C agonist (Lorcaserin) activates receptors in the CNS to reduce (migraine/appetite) __.
Appetite
Tegaserod is a 5-HT4 partial agonist w/c acts on the colon for chronic constipation but is now not used because of ______ toxicity.
Cardiovascular
SSRI is used for what?
depression, inhibits serotonin reuptake
Fibanserin is an ____ agonist and ____ antagonist used for hypoactive sexual disorder in women. This lowers serotonin in the brain and increases noerpinerphrine and dopamine NTs.
5-HT1A, 5-HT2A
Which serotonin agonists (drugs) have a shorter duration of effect for treating headache?
almotriptan, sumatriptan, rizatriptan, and zolmitriptan
Serotonin syndrome is due to an excess of 5-HT____.
5-HT2A
Serotonin sydrome happens when MAO inhibitors are given with sertonin agonists (antidepressant corticosteroids). (T/F)
TRUE
What is the first line therapy for serotonin syndrome?
Benzodiazepines (sedation)
Which agonists produce altered sensations, dizzines, muscle weakness, & neck pain?
Serotonin
Ketanserin, phenoxybenzamine, and cyproheptadine are ______ blockers.
5-HT2
