Autacoids - Serotonin Flashcards
To check for 5-HT levels in the body, check for which metabolite?
5-hydroxyindoleacetic acid (primary urinary metabolite of serotonin)
5-HT2C agonist can be used for (hypertension/depression/chemotherapy) _______.
hypertension
(Lorcaserin/Dexfenfluramine/Both) ___ are 5-HT2C agonists which can be used for obesity as appetite suppressants.
Both
Triptans is a 5-HT(1D/1B/both) ___ agonist which can activate receptors on presynaptic trigeminal nerve endings, inhibiting release of vasodilating peptides and suppressing excessive firings of these nerve endings. This can prevent migraine attacks.
Both
5-HT1D/1B agonist (Sumatriptan) is contraindicated for patients at risk for (patients undergoing cardiac surgery/coronary artery disease/both) ____.
CAD
5-HT2C agonist (Lorcaserin) activates receptors in the CNS to reduce (migraine/appetite) __.
Appetite
Tegaserod is a 5-HT4 partial agonist w/c acts on the colon for chronic constipation but is now not used because of ______ toxicity.
Cardiovascular
SSRI is used for what?
depression, inhibits serotonin reuptake
Fibanserin is an ____ agonist and ____ antagonist used for hypoactive sexual disorder in women. This lowers serotonin in the brain and increases noerpinerphrine and dopamine NTs.
5-HT1A, 5-HT2A
Which serotonin agonists (drugs) have a shorter duration of effect for treating headache?
almotriptan, sumatriptan, rizatriptan, and zolmitriptan
Serotonin syndrome is due to an excess of 5-HT____.
5-HT2A
Serotonin sydrome happens when MAO inhibitors are given with sertonin agonists (antidepressant corticosteroids). (T/F)
TRUE
What is the first line therapy for serotonin syndrome?
Benzodiazepines (sedation)
Which agonists produce altered sensations, dizzines, muscle weakness, & neck pain?
Serotonin
Ketanserin, phenoxybenzamine, and cyproheptadine are ______ blockers.
5-HT2
Ondansetron, granisetron, dolasetron, and alosetron are ____ blockers.
5-HT3
Ketanserin is used for _____.
hypertension
Which 5-HT2 blockers may help in treatment of carcinoid tumor (which secretes excess serotonin)?
Ketanserin, phenoxybenzamine, cyproheptadine
5-HT2 blockers produce diarrhea, bronchoconstriction and flushing (T/F).
TRUE
Which drug is useful for control of vomiting associated with cancer chemotherapy?
Ondansetron
What are side effects of Ketanserin?
Tachycardia, drowsiness
Side effects of ondansetron, granisetron, and dolasetron
Diarrhea, headache
Dolasetron side effects on ECG; should not be used in patients w/ heart disease
QRS, QTc prolongation
Alosetron side effects.
Constipation, fatal bowel complications
What can act as an agonist, partial agonist, and antagonist at alpha
adrenoceptors and serotonin receptors
Ergot alkaloids
