Autacoids - Eicosanoid

Question 1

Among the eicosanoid agonists, this is the only group that retains the straightchain configuration of parent ARA.

Answer 1

Leukotrienes || Cyclized ARA: Prostacyclin, Thromboxane

Question 2

PGE2 and PGF2a cause uterine _____.

Answer 2

contraction

Question 3

What is used to soften cervix at term before induction of labor with oxytocin?

Answer 3

Dinoprostone (PGE2) | Adverse effects: nausea, vomiting, diarrhea (may be used before
oxytocin)

Question 4

1. Used with the progesterone antagonist mifepristone (or methotrexate) and an effective abortificent with this combination. || 2. Used for prevention of peptic ulcers in patients who take high doses of NSAIDs.

Answer 4

Misoprostol

Question 5

What is given to maintain patency of ductus arteriosus in infants?

Answer 5

PGE1

Question 6

What is given in severe pulmonary hypertension to prevent platelet aggregation in dialysis machines?

Answer 6

Epoporstenol (Prostacyclin PGI2)

Question 7

Used in the treatment of impotence by injection into the cavernosa or as a urethral suppository

Answer 7

Alprostadil (PGE1)

Question 8

PGF2_ derivative used extensively for the topical treatment of glaucoma by reducing intraocular pressure by increasing outflow of aqueous humor

Answer 8

Latanoprost (Others: Bimatoprost, travoprost, and unoprostone)

Question 9

Eicosanoid antagonist that Inhibit the production of ARA by phospholipases –> inhibit COX2 synthesis AND treat inflammation

Answer 9

Corticosteroids B107

Question 10

Eicosanoid antagonist that inhibits lipoxygenase (zileuton) and LTD4; treats asthma

Answer 10

Leukotriente antagonists

Question 11

LTE4 receptor antagonist drugs include:

Answer 11

(zafirlukast, montelukast)

Question 12

Potent vasodilator autacoid produced from arginine in the body, and the active metabolite of drugs that release it (NO donors)

Answer 12

Nitric Oxides

Question 13

____ (Exogeneous/Endogenous) NO donors: NO is released from nitroprusside, nitrates and nitrites

Answer 13

Exogenous

Question 14

NO is a powerful vasodilator in all vascular beds and a potent relaxant in what kind of tissue?

Answer 14

Smooth muscle (cGMP facilitates the dephosphorylation and inactivation of myosin light chains relaxation of smooth muscle)

Question 15

NO’s effects on cell adhesion include reduced ____ aggregation and _____ adhesion.

Answer 15

platelet; neutrophil

Question 16

Excessive ___ (either inhaled or from nitrites) convert hemoglobin to methemoglobin and may result in hypoxia.

Answer 16

NO