Autacoids

Question 1

Reversible competitive of H1
receptors
• Cross BBB and enter the CNS readily⇒ sedation
• Short duration of action (t ½ 4-6 hrs)
• E.g diphenhydramine,
chlorpheniramine and promethazine

Answer 1

1st generation (sedating antihistamines)

Question 2

• Reversible competitive of H1
receptors
• Do not ross BBB ⇒ no sedation
• Long duration of action (t ½ 24 hrs)
• E.g Loratadine, cetirizine and
terfenadine

Answer 2

2nd generation (low-sedating antihistamines)

Question 3

Indications:
• Allergic conjunctivitis, urticaria, angioedema.
• Adjunctive in anaphylaxis (H1antagonist, and epinephrine must also be used in anaphylaxis)
• Sedative/sleep aid.
• Antivertigo

Answer 3

1st gen H1 blockers

Question 4

• Antiemetic: prophylactic for motion sickness (…………)
• Morning sickness: (…………………)
• Local anesthetic: (……………)
• Antitussive (…………….)
• Tranquilizing effects: ……………

Answer 4

promethazine
meclizine, cyclizine
diphenhydramine
diphenhydramine
Hydroxyzine

Question 5

• Marked sedation; disturbed coordination
• (increase in automobile accidents).
• Atropine-like signs and symptoms:
• dry mouth; fixed, dilated pupils; flushing, and gastrointestinal symptoms.
• Impaired cognitive function in elderly patients
• (attributed to anticholinergic side effects).
• Allergic reactions with topical use.
Side effects of:-

Answer 5

1st gen H1 blockers

Question 6

5-HT1A agonist used as anxiolytic agent (maintenance).

Answer 6

Buspirone

Question 7

5-HT1D agonist for migraine (Treatment of acute migraine).

Answer 7

Sumatriptan

Question 8

Triptans (Sumatriptan) are contraindicated in patients with known or suspected .……………………….

Answer 8

coronary artery disease

Question 9

• Antihypertensive (vasodilator)
• Antithrombotic (inhibit platelet
activation)

Answer 9

NITRIC OXIDE